Publications by authors named "Eun Hyun Jung"
Background: The objective of this was to identify functional single nucleotide polymorphisms (SNPs) in cyclin-dependent kinases (CDKs) and cyclins that are associated with risk of human cancer.
Methods: First, 45 SNPs in CDKs and cyclins were analyzed in 106 lung cancers and 108 controls for a pilot study. One SNP (reference SNP [rs] 769236, +1 guanine to adenine [G→A]) at the promoter region of cyclin A2 (CCNA2) also was analyzed in 1989 cancers (300 breast cancers, 450 colorectal cancers, 450 gastric cancers, 367 hepatocellular carcinomas, and 422 lung cancers) and in 1096 controls.
Article Synopsis
- The study aimed to find epigenetic markers in plasma that could help detect colorectal cancer at an early stage.
- Researchers analyzed the methylation patterns of 10 genes in tissue and plasma samples from patients with colorectal cancer and healthy individuals, using a method called methylation-specific PCR.
- The findings suggested that specific genes (APC, MGMT, RASSF2A, and Wif-1) could serve as effective biomarkers, showing high sensitivity (86.5%) and specificity (92.1%) for early detection of the disease in plasma samples.
Background: CpG island hypermethylation has been reported at the promoter region of many tumor suppressor genes in colorectal cancers. However, there are significant interindividual differences in the degree of DNA methylation in colorectal cancers. The objective of the current study was to understand whether single nucleotide polymorphisms (SNPs) around the promoter of a gene are implicated in the interindividual differences of CpG island hypermethylation.
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