Publications by authors named "Eun Ho Cho"
Article Synopsis
- FAM19A5 is mainly a protein found in the brain, but recent studies suggest it plays a role in regulating smooth muscle function as an adipokine derived from fat cells.
- Our research examined FAM19A5 levels in different tissues from various mouse models, finding that its transcript levels were significantly higher in the brain compared to peripheral tissues like fat.
- We also discovered that the FAM19A5 protein was barely detectable in fat and reproductive tissues, and it doesn't seem to interact with the S1PR2 receptor in key cellular functions.
Article Synopsis
- Graphene oxide (GO) is a valuable material in advanced engineering applications like soft robotics and flexible devices, requiring an understanding of its properties in solution.
- GO's polydispersity—variability in particle size—affects its mechanical behavior and flowability, but research on this topic is limited.
- This study explores how GO's polydispersity influences its rheological properties and yielding behavior, using techniques like rheometry and microscopy, finding that higher polydispersity improves these characteristics, which is useful for applications like 3D printing.
Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents an unmet clinical need. Therefore, future studies should provide evidence regarding the mechanisms of potential targets that can overcome the resistance as well as alleviate pain. Here, we show that the emergence of cisplatin resistance is highly associated with EGFR hyperactivation, and that EGFR hyperactivation is arisen by a transcriptional increase in the pain-generating channel, TRPV1, via NANOG.
View Article and Find Full Text PDFDrug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been used to predict drug-induced PL in humans. We established three-dimensional (3D) human liver organoids as described previously and investigated their liver characteristics through multiple analyses.
View Article and Find Full Text PDFThis study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreatic injury dog model. Acute pancreatitis was induced by infusion of cerulein for 2 h (7.5 μg/kg/h).
View Article and Find Full Text PDFEnhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues.
View Article and Find Full Text PDFInterstitial cystitis (IC) is a chronic bladder dysfunction characterized as urinary frequency, urgency, nocturia, and pelvic pain. The changes in urethra may wind up with the bladder changes in structure and functions, however, the functions of the urethra in IC remains elusive. The aim of this study was to understand the perturbed gene expression in urethra, compared with urinary bladder, associated with the defected urodynamics.
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