Publications by authors named "Eun Hee KIM"
During nasal polyp (NP) development, activated T cells differentiate into T helper (Th) 1, Th2, and Th17 cells. Additionally, regulatory T cells (Tregs) that have an immune suppressive function are involved in the pathophysiology of chronic rhinosinusitis (CRS) with NP (CRSwNP). Tregs can act as effector cells that produce inflammatory cytokines, such as interleukin (IL)-17A.
View Article and Find Full Text PDFBackground: Processed electroencephalogram (EEG) indices are widely used to monitor anesthetic depth. However, their reliability in children under 2 years of age remains questionable. During anesthesia maintenance in this age group, processed EEG indices frequently exhibit unexpectedly elevated values that exceed the intended target range.
View Article and Find Full Text PDFObjective: There is insufficient evidence to determine the effectiveness of treating allergic rhinitis with a patch laser affix to the skin as opposed to direct intranasal irradiation of the nasal mucosa. We aimed to evaluate the effect of the microneedle patch laser with multiple wavelengths in an allergic rhinitis (AR) mouse model and its underlying mechanism.
Methods: The microneedle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa.
Intraoperative transfontanelle ultrasonography for pediatric patients.
Anesth Pain Med (Seoul)
October 2024
Cerebral blood flow (CBF) plays a vital role in delivering cerebral oxygen, and the accurate assessment of CBF is crucial for the intraoperative management of critically ill infants. Although the direct measurement of CBF is challenging, CBF velocity (CBFV) can be assessed using transcranial Doppler. Recent advances in point-of-care ultrasound have introduced brain ultrasound as a feasible intraoperative option, in which transfontanelle ultrasonography (TFU) has been applied to measure the CBFV through the anterior fontanelle.
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- High-flow nasal oxygenation (HFNO) is shown to effectively prolong safe apnea time in pediatric patients while maintaining adequate oxygen levels, outperforming buccal oxygenation (BO).
- In a study involving 38 patients aged 0-10, the HFNO group achieved a 100% success rate in extending acceptable apnea duration, while the BO group had a 76% success rate.
- The findings suggest that HFNO is the better method for oxygenation during apnea in children with their mouths open, although BO can serve as a backup option when HFNO is not accessible.
Association between estimated glucose disposal rate and subclinical coronary atherosclerosis.
Nutr Metab Cardiovasc Dis
January 2025
Background And Aims: The estimated glucose disposal rate (eGDR) is an easily accessible clinical parameter for assessing insulin resistance in patients with diabetes mellitus. In this study, we aimed to investigate the link between eGDR and subclinical coronary atherosclerosis in an asymptomatic middle-aged Korean population.
Methods And Results: This study involved 4004 subjects who underwent routine health checkups with coronary multidetector computed tomography (MDCT) at Asan Medical Center from 2007 to 2011, among whom 913 had a follow-up analysis through 2014.
Association between atherogenic dyslipidemia and muscle quality defined by myosteatosis.
Front Endocrinol (Lausanne)
August 2024
Background: Myosteatosis, ectopic fat accumulation in skeletal muscle, is a crucial component of sarcopenia, linked to various cardiometabolic diseases. This study aimed to analyze the association between dyslipidemia and myosteatosis using abdominal computed tomography (CT) in a large population.
Methods: This study included 11,823 patients not taking lipid-lowering medications with abdominal CT taken between 2012 and 2013.
Article Synopsis
- Traditional methods for detecting monoclonal proteins (M-protein) in plasma cell disorders are being compared to newer mass spectrometry (MS) techniques, which may offer better sensitivity.
- The study utilized various antibody affinity beads and mass spectrometry methods to analyze 50 samples, revealing that abnormal samples had identifiable monoclonal peaks, while normal samples had polyclonal peaks.
- The results suggested that the NB-MALDI-TOF method is a viable alternative to conventional tests like immunofixation electrophoresis (IFE), showing similar sensitivity and reliability in detecting M-protein.
Article Synopsis
- Hypoxaemia is common during pediatric laryngeal microsurgery, prompting a study on the effectiveness of the oxygen reserve index as a monitoring tool.
- In a randomised controlled trial involving 88 pediatric patients, the study aimed to see if tracking the oxygen reserve index could lower the occurrence of dangerously low oxygen levels (SpO2 ≤ 90%) during surgery.
- Results showed that the oxygen reserve index monitoring did not significantly reduce the overall rate of low oxygen levels, but it was more effective in managing rescue interventions compared to the control group.
Article Synopsis
- * The study focused on a newly developed silkworm larva powder (SMSP) to assess its safety and potential toxicity for human consumption.
- * Toxicity tests on rats showed no adverse effects up to a dose of 2500 mg/kg/day, indicating that SMSP is safe for use in food products and health applications.
Article Synopsis
- Methylene blue (MB) recently completed a Phase-3 trial for Alzheimer's treatment, focusing on its effects on tau protein aggregation.
- Research showed that MB induces disulfide bond formation in tau proteins, changing their structure significantly.
- The oxidized form, methylthioninium (MT), specifically targets certain cysteine residues in tau, potentially preventing tau fibrillation under low oxygen conditions in the brain.
Multiple bacterial genera take advantage of the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin to invade host cells. Secretion of the MARTX toxin by Vibrio vulnificus, a deadly opportunistic pathogen that causes primary septicemia, the precursor of sepsis, is a major driver of infection; however, the molecular mechanism via which the toxin contributes to septicemia remains unclear. Here, we report the crystal and cryo-electron microscopy (EM) structures of a toxin effector duet comprising the domain of unknown function in the first position (DUF1)/Rho inactivation domain (RID) complexed with human targets.
View Article and Find Full Text PDFBackground: In 2023, the concept of metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced as an alternative to non-alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications.
Methods: This cross-sectional study included 18 154 participants (11 551 [63.
Article Synopsis
- - This study investigates the effects of positive-end-expiratory pressure (PEEP) on how long infants can experience non-hypoxic apnea during anesthesia induction while receiving a high level of oxygen (0.8).
- - The research involved 84 infants under 1 year, comparing outcomes between those receiving PEEP and those without it, with findings indicating that PEEP reduced atelectasis and increased non-hypoxic apnea time only in infants 6 months or younger.
- - The results show that while PEEP is beneficial for younger infants in minimizing lung collapse and prolonging safe apnea, it does not provide similar benefits for infants older than 6 months.
Article Synopsis
- * Researchers checked records from 6,691 sedation cases and found that 21.8% had sedation failure, meaning the kids didn’t sleep enough for the procedure.
- * They identified factors that made sedation less successful, like being in the hospital, having certain medical conditions, or needing long and painful procedures.
Article Synopsis
- Colorectal cancer is aggressive and linked to histamine signaling; this study investigates the anticancer effects of terfenadine on HCT116 cells.
- Terfenadine significantly reduces HCT116 cell viability by disrupting H1 receptor signaling and inducing apoptosis through various molecular pathways, including changes in Bax/Bcl-2 ratios and caspase activation.
- The findings suggest that terfenadine not only impairs STAT3 signaling but also shows potential as an effective treatment for colorectal cancer, evidenced by its ability to slow tumor growth in xenograft models.
Ischemic stroke is a major cause of mortality worldwide. Proper etiological subtyping of ischemic stroke is crucial for tailoring treatment strategies. This study explored the utility of circulating microRNAs encapsulated in extracellular vesicles (EV-miRNAs) to distinguish the following ischemic stroke subtypes: large artery atherosclerosis (LAA), cardioembolic stroke (CES), and small artery occlusion (SAO).
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- The study aimed to explore the link between levels of atmospheric particulate matter on surgery day and instances of intra-operative hypoxaemia (low oxygen levels) in children under general anaesthesia.
- It was conducted retrospectively at a single center, analyzing data from children aged 18 or younger who underwent surgeries from January 2019 to October 2020, with air quality data sourced from public records.
- Results indicated that higher levels of particulate matter (≥81 μg m -3) were associated with an increased risk of hypoxaemia during surgery, suggesting air pollution could impact children's health during medical procedures.
Article Synopsis
- The study investigates the impact of Analgesia Nociception Index (ANI) guided analgesia on opioid use and pain management during surgery for children with moyamoya disease.
- Conducted at Seoul National University Children's Hospital, it includes 40 children undergoing encephaloduroarteriosynangiosis, comparing ANI-guided and standard analgesia methods.
- Results show that the ANI group used less sufentanil and reported lower pain scores post-surgery, with fewer instances of nausea, suggesting this method improves analgesic efficacy in pediatric anesthesia.
Article Synopsis
- Persistent inflammation is increasingly recognized as a significant contributor to cancer development, with evidence from both preclinical and clinical studies.
- Cyclooxygenase-2 (COX-2) is an important enzyme linked to inflammation that is often overexpressed in colorectal cancer and other cancers, particularly when inflammation does not resolve.
- The review discusses COX-2's complex role, including both its pro-inflammatory activities and its ability to produce anti-inflammatory substances, which may explain the adverse effects of long-term COX-2 inhibitors used in cancer prevention trials.
Determination of optimal positive end-expiratory pressure using electrical impedance tomography in infants under general anesthesia: Comparison between supine and prone positions.
Paediatr Anaesth
August 2024
Article Synopsis
- The study investigated the best level of positive end-expiratory pressure (PEEP) for infants under general anesthesia in both supine and prone positions using electrical impedance tomography (EIT).
- It included 30 infants and found that the optimal PEEP was significantly higher in the prone position (10.9 cmHO) compared to the supine position (6.1 cmHO).
- Results indicated that EIT is a useful method for determining individualized PEEP levels, as ventilation parameters improved in the prone position despite increased airway pressures.
Article Synopsis
- Nine bacteria were isolated from the episphere of (L.) Dumort., with the YSL2 strain demonstrating the highest antimicrobial activity and uniqueness based on 16S rRNA analysis.
- YSL2 underwent further testing, including phenotypic characterization and whole-genome sequencing, revealing its close relation to another strain, SNG49, and the presence of gene clusters for antimicrobial compounds.
- Large-scale cultivation of YSL2 led to the identification of two cyclic hexapeptides, maritiamides A and B, which showed strong antibacterial properties against certain bacteria while mildly inhibiting others.
Article Synopsis
- A study was conducted to evaluate if using smart glasses for ultrasound-guided catheterization improves success rates for less experienced anaesthesia trainees.
- The trial involved 122 children needing radial artery cannulation, comparing those using smart glasses to a control group using traditional ultrasound methods.
- Results showed that the smart glasses group had a significantly higher first-attempt success rate (89.8% vs. 71.7%) and fewer overall attempts, complications, and use of a more complex technique.
Article Synopsis
- Three diterpenoids were isolated from the fruits of Vitex rotundifolia and their structures were analyzed using spectroscopic techniques.
- In experiments with RAW264.7 cells stimulated by lipopolysaccharides, the compounds reduced levels of reactive oxygen species and nitric oxide in a dose-dependent manner.
- At a concentration of 25 μM/mL, the compounds also lowered the expression of pro-inflammatory cytokines, with compound 3 showing the strongest inhibitory effect.