Publications by authors named "Eun Ha Kang"

Objective: We aim to compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl-peptidase-4 inhibitors (DPP4is), individually within stone never- and ever-formers.

Research Design And Methods: Using the 2010-2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing initiators of SGLT2is versus DPP4is. The primary outcome was incident nephrolithiasis.

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Objectives: We investigated the prevalence of anti-thyroid autoantibodies and thyroid dysfunction, and their association with clinical and laboratory features in Korean patients with primary Sjögren's syndrome (pSS) without overt thyroid illnesses.

Methods: We consequently included 196 pSS patients (190 women) and cross-sectionally collected clinical and laboratory data including the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) and Patient Reported Index (ESSPRI). The fatigue-dominant group was defined as those in the highest quartile of the fraction of fatigue, calculated as the ESSPRI fatigue score divided by the total ESSPRI score.

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Article Synopsis
  • - The study analyzed how poor prognostic factors (PPFs), such as functional limitations and bone erosions, impact remission rates and the need for advanced therapies (b/tsDMARDs) in a large group of Korean patients with rheumatoid arthritis (RA).
  • - Patients were divided into three groups based on the number of PPFs they had, with Group H (≥3 PPFs) showing more severe disease and poorer health outcomes compared to Groups L (0-1 PPFs) and M (2 PPFs).
  • - The findings indicate that patients in Group H found it much harder to achieve remission over five years and were more likely to require b/tsDMARD treatment, suggesting that higher P
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Objective: To compare the risk of dementia associated with sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus dipeptidyl peptidase-4 (DPP-4) inhibitors in adults aged 40-69 years with type 2 diabetes.

Design: Population based cohort study.

Setting: Korean National Health Insurance Service data, 2013-21.

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Objective: Giant cell arteritis (GCA) is a large-vessel vasculitis that primarily affects elderly individuals. However, data regarding Korean patients with GCA are scarce owing to its extremely low prevalence in East Asia. This study aimed to investigate the clinical characteristics of Korean patients with GCA and their outcomes, focusing on relapse.

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder affecting the sacroiliac joints and axial spine. Along with pharmacotherapy, non-pharmacological interventions for axSpA are crucial and constitute the cornerstone of treatment. Here, we review the evidence for non-pharmacological treatment of axSpA as a basis for the 2023 Korean treatment recommendations for patients with axSpA.

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Article Synopsis
  • The study aimed to compare the risk of kidney stones (urolithiasis) in gout patients starting treatment with allopurinol versus benzbromarone.
  • Using a large national health database, researchers analyzed data from over 61,000 patients and found that those using allopurinol had a significantly lower incidence of kidney stones compared to those using benzbromarone.
  • The results suggest that allopurinol is a safer option for gout management, especially in patients with high cardiovascular risk, which is important for healthcare providers to consider when prescribing treatments.
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Article Synopsis
  • The study explored how socioeconomic status (SES) affects the use of biologic treatments in rheumatoid arthritis (RA) patients, revealing significant disparities based on income and education levels.
  • Out of 5,077 patients, only 393 were using biologics, with low-income and low-education individuals being less likely to access these treatments despite having worse disease conditions.
  • The results stress the need to address healthcare inequalities by factoring in socioeconomic dimensions to improve access to biologics and RA management for all patients.
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Background: The comparative risk of cause-specific mortality in patients with Behçet disease (BD) vs. the general population is not known.

Objectives: To compare the risk of all-cause and cause-specific mortality in patients with BD vs.

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Behçet syndrome (BS) is a chronic inflammatory disease with multiorgan manifestations. However, muscular involvement in BS has rarely been reported. Herein, we report the case of a 30-year-old male with BS who had recurring pain and swelling of the lower legs.

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Background: To compare infectious risk between JAK inhibitors (JAKis) versus TNF inhibitors (TNFis) among rheumatoid arthritis (RA) patients in Korea.

Methods: Using 2009-2019 Korea National Health Insurance Service database, we conducted a cohort study on RA patients initiating a JAKi or TNFi. The primary outcomes were herpes zoster (HZ), serious bacterial (SBI), and opportunistic infections (OI).

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We aimed to develop evidence-based recommendations for treating axial spondylarthritis (axSpA) in Korea. The development committee was constructed, key clinical questions were determined, and the evidence was searched through online databases including MEDLINE, Embase, Cochrane, KoreaMed, and Kmbase. Systematic literature reviews were conducted, quality of evidence was determined, and draft recommendations were formulated according to the Grading of Recommendations Assessment, Development, and Evaluations methodology.

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We aimed to develop evidence-based recommendations for treating axial spondylarthritis (axSpA) in Korea. The development committee was constructed, key clinical questions were determined, and the evidence was searched through online databases including MEDLINE, Embase, Cochrane, KoreaMed, and KMbase. Systematic literature reviews were conducted, quality of evidence was determined, and draft recommendations were formulated according to the Grading of Recommendations Assessment, Development, and Evaluations methodology.

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High-throughput sequencing identified a cytorhabdovirus, tentatively named "cnidium virus 2" (CnV2), in Cnidium officinale, and Sanger sequencing confirmed the genome sequence. CnV2 is 13,527 nucleotides in length and contains seven open reading frames in the order 3'-N-P-3-4-M-G-L-5', separated by intergenic regions. The full-length nucleotide sequence of CnV2 shares 19.

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The complete genome sequence of a novel virus found infecting Cnidium officinale, which we have named "cnidium polerovirus 1" (CnPV1), is 6,090 nucleotides in length, similar to those of other poleroviruses. Seven open reading frames (ORF0-5 and ORF3a) were predicted in this genome. CnPV1 shares 32.

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The diagnostic performance of band intensity (BI) cut-offs, adjusted by a positive control band (PCB) in a line-blot assay (LBA) for myositis-related autoantibodies (MRAs) is investigated. Sera from 153 idiopathic inflammatory myositis (IIM) patients with available immunoprecipitation assay (IPA) data and 79 healthy controls were tested using the EUROLINE panel. Strips were evaluated for BI using the EUROLineScan software, and the coefficient of variation (CV) was calculated.

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Article Synopsis
  • The study aimed to compare clinical outcomes between rheumatoid arthritis (RA) patients with early menopause (before 45) and usual menopause (45 and older), focusing on how early menopause affects disease activity and patient-reported outcomes over time.
  • Out of 2878 postmenopausal women surveyed, those with early menopause (437 patients) were found to be younger and had worse initial health indicators compared to the usual menopause group, including higher disease activity and lower quality of life scores.
  • The analysis showed that early menopause significantly impacted the progression of disease activity and patient-reported outcomes over a five-year period, leading to worse health-related quality of life and increased disability scores in the early menopause
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Objectives: To explore the course of lung function and RA disease activity and predictive factors for deteriorating lung function in patients with RA-interstitial lung disease (ILD).

Methods: The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients with RA-ILD were enrolled and followed up annually for 3 years for RA disease activity and ILD status assessment.

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