Anti-atherogenic effects of 3,4-Dihydroxy hydrocinnamides.

3,4-Dihydroxy hydrocinnamides 2 and 3 exhibited the anti-atherogenic activities by inhibiting the formation of aortic fatty streak in high cholesterol-fed rabbits.

Hypocholesterolemic activity of hesperetin derivatives.

Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.