Publications by authors named "Eumildo de Campos Junior"
Tissue damage observed in the clinical forms of chronic symptomatic Chagas disease seems to have a close relationship with the intensity of the inflammatory process. The objective of this study was to investigate whether the () and () polymorphisms are associated with the cardiac and digestive clinical forms of chronic Chagas disease. Possible influence of these genes polymorphisms on the left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease was also evaluated.
View Article and Find Full Text PDFPercutaneous endoscopic gastrostomy is used to provide enteral nutritional support for patients with obstructive oropharyngeal or esophageal neoplasms. The placement of the catheter is considered safe, with few complications. Despite this, a specific complication that is considered rare, has been increasingly described in the literature, i.
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- - The study examined plasma levels of the chemokines CCL3 and CCL4 in patients with different clinical forms of chronic Chagas disease, focusing on those with and without left ventricular systolic dysfunction (LVSD).
- - It involved analyzing plasma samples from 75 patients using ELISA and Milliplex® MAP assay, confirming the T. cruzi infection.
- - Results showed no significant level differences of CCL3 and CCL4 between digestive and cardiac forms of Chagas disease, and found that while LVSD patients had higher chemokine levels, CCL3 and CCL4 do not seem to affect susceptibility to the disease forms or influence LVSD development.
Article Synopsis
- - Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to various health issues like heart problems and digestive tract complications, but the factors determining why some people are symptomatic and others are not remain unclear.
- - This study involved 339 adults with chronic Chagas disease and aimed to explore how different blood group systems (ABO, Secretor, and Lewis) might be linked to the disease’s clinical forms.
- - While no significant differences were found between patients and healthy controls for the blood group systems, the combination of B plus AB Secretor phenotypes was significantly more common in patients with megacolon and megaesophagus compared to those with A plus O Secretor phenotypes.
The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the variable clinical course of this disease are known. This study investigated whether the CCR5Δ32 (rs333) and CCR5 59029 A/G (promoter region--rs1799987) polymorphisms of the CCR5 gene are associated with different clinical forms of chronic Chagas disease and with the severity of left ventricular systolic dysfunction in patients with chronic Chagas heart disease (CCHD).
View Article and Find Full Text PDFThe Serra-Dória procedure has been used in the treatment of advanced or relapsed megaesophagus due to Chagas disease. Little is known, however, about cardiovascular complications following this procedure. The purpose of this study was to settle independent predictors of cardiovascular complications following the Serra-Dória procedure in patients with megaesophagus secondary to chronic Chagas disease.
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