Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates.

The tethering together of sister chromatids by the cohesin complex ensures their accurate alignment and segregation during cell division. In vertebrates, sister chromatid cohesion requires the activity of the ESCO2 acetyltransferase, which modifies the Smc3 subunit of cohesin. It was shown recently that ESCO2 promotes cohesion through interaction with the MCM replicative helicase.

antibacterial and time-kill assay of ethanolic extract of bark on multidrug resistant bacteria isolated from diabetic foot lesions.

This study reported the antimicrobial activity of the bark extract of on multidrug resistant bacteria isolated from Diabetic Foot Infections. Antibacterial activity of the bark extract was evaluated by agar Disk-Diffusion (DD), Broth Dilution (BD), Checkerboard and Time-kill methods. The extract showed a significant antibacterial activity against all groups of bacteria tested.