Machine Learning-Based Diagnosis of Chronic Subjective Tinnitus With Altered Cognitive Function: An Event-Related Potential Study.

Objectives: Due to the absence of objective diagnostic criteria, tinnitus diagnosis primarily relies on subjective assessments. However, its neuropathological features can be objectively quantified using electroencephalography (EEG). Despite the existing research, the pathophysiology of tinnitus remains unclear.

Complete genome sequence of strain TDY-1, an odor-reducing bacterium isolated from livestock wastewater.

We report the complete genome sequence of TDY-1 an odor-reducing strain isolated from livestock wastewater on a pig farm. Its genome consists of a 2.97-Mb chromosome.

Complete genome sequence of strain JD2-26, a potential pollutant-reducing bacterium isolated from a municipal solid waste landfill facility.

We report here the complete genome sequence of strain JD2-26 isolated from a municipal solid waste landfill facility. The genome consists of a 6.32-Mbp chromosome and a plasmid having a total of 6,100 genes, including 5,914 coding sequences.

Complete genome sequence of a methanotrophic bacterium, strain 22M6SE5-12 isolated from a freshwater sediment environment.

We assembled the complete genome of strain 22M6SE5-12 isolated from a freshwater sediment in South Korea. The genome consists of a 4.36-Mbp chromosome and two plasmids and has 3,961 coding sequences, 12 rRNA genes, and 55 tRNA genes.

Electroencephalography-based endogenous phenotype of diagnostic transition from major depressive disorder to bipolar disorder.

The neuropathology of mood disorders, including the diagnostic transition from major depressive disorder (MDD) to bipolar disorder (BD), is poorly understood. This study investigated resting-state electroencephalography (EEG) activity in patients with MDD and those whose diagnosis changed from MDD to BD. Among sixty-eight enrolled patients with MDD, the diagnosis of 17 patients converted to BD during the study period.

P1 and N1 Characteristics in Individuals with Normal Hearing and Hearing Loss, and Cochlear Implant Users: A Pilot Study.

It has been reported in many previous studies that the lack of auditory input due to hearing loss (HL) can induce changes in the brain. However, most of these studies have focused on individuals with pre-lingual HL and have predominantly compared the characteristics of those with normal hearing (NH) to cochlear implant (CI) users in children. This study examined the visual and auditory evoked potential characteristics in NH listeners, individuals with bilateral HL, and CI users, including those with single-sided deafness.

Enhanced astaxanthin production in Haematococcus lacustris by electrochemical stimulation of cyst germination.

This study investigated the technical feasibility of using electrogermination to activate dormant cysts as an inoculum for subsequent 14-d photosynthetic astaxanthin production in Haematococcus lacustris. Electrotreatment affected the cell viability, surface charge, and morphology of H. lacustris cysts.

Community recovery of benthic macroinvertebrates in a stream influenced by mining activity: Importance of microhabitat monitoring.

The decrease in freshwater biodiversity owing to anthropogenic disturbances such as mining activity is a global challenge; hence, there is an urgent need for systematic approaches to continuously monitor such disturbances and/or the recovery of biodiversity in freshwater habitats. The Hwangjicheon Stream is the source of South Korea's longest river and has been subjected to runoff from coal mining. We investigated changes in the diversity of the benthic macroinvertebrate community in various microhabitats, including riffle, run, and pool, to monitor the recovery of biodiversity in the stream following the improvement of a mining water treatment plant in 2019.

Chlorophyll Synthesis in by Chlorophyll Synthase of .

The production of phytylated chlorophyll (Chl ) in , which uses phytylated bacteriochlorophyll (BChl ), is the first step in expanding the light absorption spectra. Unlike the chlorophyll synthase (ChlG) of the sp. PCC6803, ChlGs of angiosperms, including , , , and , showed bacteriochlorophyll synthase activity and resistance to inhibition by bacteriochlorophyllide (BChlide ), geranylgeranylated BChl (BChl ), and BChl , collectively called bacteriochlorins.

The Photoactive Photosynthetic Reaction Center of a Rhodobacter sphaeroides Mutant Lacking 3-Vinyl (Bacterio)Chlorophyllide Hydratase Contains 3-Vinyl Bacteriochlorophyll .

Rhodobacter sphaeroides mutant BF-lacking 3-vinyl (bacterio)chlorophyllide hydratase (BchF)-accumulates chlorophyllide (Chlide ) and 3-vinyl bacteriochlorophyllide (3V-Bchlide ). BF synthesizes 3-vinyl bacteriochlorophyll (3V-Bchl ) through prenylation of 3V-Bchlide and assembles a novel reaction center (V-RC) using 3V-Bchl and Mg-free 3-vinyl bacteriopheophytin (3V-Bpheo ) at a molar ratio of 2:1. We aimed to verify whether a -deleted R.

Photoautotrophic Growth Rate Enhancement of sp. PCC6803 by Heterologous Production of 2-Oxoglutarate:Ferredoxin Oxidoreductase from .

2-Oxoglutarate:ferredoxin oxidoreductase from Chlorobaculum tepidum (CtOGOR) is a carbon-fixing enzyme in the reductive TCA cycle that reversibly carboxylates succinyl-CoA to yield 2-oxoglutarate. CtOGOR is a heterotetramer of two large (α = 68 kDa) and two small (β = 38 kDa) subunits. The αβ protomer harbors one thiamine pyrophosphate and two 4Fe-4S clusters.

Sustainability of in vitro light-dependent NADPH generation by the thylakoid membrane of Synechocystis sp. PCC6803.

Background: NADPH is used as a reductant in various biosynthetic reactions. Cell-free bio-systems have gained considerable attention owing to their high energy utilization and time efficiency. Efforts have been made to continuously supply reducing power to the reaction mixture in a cyclical manner.

Multi-scale causality analysis between COVID-19 cases and mobility level using ensemble empirical mode decomposition and causal decomposition.

The global spread of the coronavirus disease 2019 (COVID-19) pandemic has affected the world in many ways. Due to the communicable nature of the disease, it is difficult to investigate the causal reason for the epidemic's spread sufficiently. This study comprehensively investigates the causal relationship between the spread of COVID-19 and mobility level on a multi time-scale and its influencing factors, by using ensemble empirical mode decomposition (EEMD) and the causal decomposition approach.

Evaluation of the Impacts of Abandoned Mining Areas: A Case Study with Benthic Macroinvertebrate Assemblages.

Mining activities are among the most long-lasting anthropogenic pressures on streams and rivers. Therefore, detecting different benthic macroinvertebrate assemblages in the areas recovered from mining activities is essential to establish conservation and management plans for improving the freshwater biodiversity in streams located near mining areas. We compared the stability of benthic macroinvertebrate communities between streams affected by mining activities (Hwangjicheon: NHJ and Cheolamcheon: NCA) and the least disturbed stream (Songjeonricheon: NSJ) using network analysis, self-organizing map, and indicator species analysis.

In-vivo estimation of tissue electrical conductivities of a rabbit eye for precise simulation of electric field distributions during ocular iontophoresis.

Precise estimation of electrical conductivity of the eyes is important for the accurate analysis of electric field distributions in the eyes during ocular iontophoresis. In this study, we estimated the tissue electrical conductivities of a rabbit eye, which has been widely employed for neuro-ophthalmological experiments, through an in vivo experiment for the first time. Electrical potentials were measured at multiple locations on the skin, while weak currents were transmitted into the skin via two surface electrodes attached to the skin around the eye.

Application of naïve Bayesian approach in detecting reproducible fatal collision locations on freeway.

Detecting high-collision-concentration locations based solely on collision frequency may produce different results compared to those considering the severities of the collisions. In particular, it can lead government agencies focusing sites with a high collision frequency while neglecting those with a lower collision frequency but a higher percentage of injury and fatal collisions. This study developed systematic ways of detecting reproducible fatal collision locations (R) using the naïve Bayes approach and a continuous risk profile (CRP) that estimates the true collision risk by filtering out random noise in the data.

Spatiotemporal filtering method for detecting kinematic waves in a connected environment.

Backward-moving kinematic waves (KWs) (e.g., stop-and-go traffic conditions and a shock wave) cause unsafe driving conditions, decreases in the capacities of freeways, and increased travel time.

Differences in Mechanisms of Steroid Therapy and Olfactory Training for Olfactory Loss in Mice.

Objective: Steroid therapy and olfactory training are common treatments for olfactory loss. Systemic steroid treatment is the most effective approach for treating sinonasal olfactory loss. Olfactory training is typically effective for treating sensorineural olfactory loss.

Development of a Brain-Computer Interface Toggle Switch with Low False-Positive Rate Using Respiration-Modulated Photoplethysmography.

Asynchronous brain-computer interfaces (BCIs) based on electroencephalography (EEG) generally suffer from poor performance in terms of classification accuracy and false-positive rate (FPR). Thus, BCI toggle switches based on electrooculogram (EOG) signals were developed to toggle on/off synchronous BCI systems. The conventional BCI toggle switches exhibit fast responses with high accuracy; however, they have a high FPR or cannot be applied to patients with oculomotor impairments.

Can Anodal Transcranial Direct Current Stimulation Increase Steady-State Visual Evoked Potential Responses?

Background: It has been frequently reported that non-negligible numbers of individuals have steady-state visual evoked potential (SSVEP) responses of low signal-to-noise-ratio (SNR) to specific stimulation frequencies, which makes detection of the SSVEP difficult especially in brain-computer interface applications. We investigated whether SSVEP can be modulated by anodal transcranial direct-current stimulation (tDCS) of the visual cortex.

Methods: Each participant participated in two 20-min experiments-an actual tDCS experiment and a sham tDCS experiment-that were conducted on different days.

Building a Thermostable Metabolon for Facilitating Coenzyme Transport and In Vitro Hydrogen Production at Elevated Temperature.

To facilitate coenzyme transport and in vitro enzymatic hydrogen production, a multi-enzyme metabolon comprising a miniscaffoldin containing three cohesins, a dockerin-containing mutant dehydrogenase, a dockerin-containing diaphorase, and a Histidine-tagged (His-tagged) NiFe hydrogenase was constructed. As the NiFe hydrogenase has very complicated structure and cannot be fused directly with a dockerin, a bifunctional peptide was designed. The bifunctional peptide, in which one terminus contains a modified dockerin binding the cohesin of the miniscaffoldin and the other, after chemical modification, binds the His-tag of NiFe hydrogenase, enabled His-tagged proteins to be integrated into the cohesin-dockerin-based metabolon.

Advanced water splitting for green hydrogen gas production through complete oxidation of starch by in vitro metabolic engineering.

Starch is a natural energy storage compound and is hypothesized to be a high-energy density chemical compound or solar fuel. In contrast to industrial hydrolysis of starch to glucose, an alternative ATP-free phosphorylation of starch was designed to generate cost-effective glucose 6-phosphate by using five thermophilic enzymes (i.e.