Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling.

Reproduction is a process that is extremely sensitive to changes in nutritional status. The nutritional control of oogenesis via insulin signaling has been reported; however, the mechanism underlying its sensitivity and tissue specificity has not been elucidated. Here, we determined that Drosophila Makorin RING finger protein 1 gene (Mkrn1) functions in the metabolic regulation of oogenesis.

Makorin 1 Regulates Developmental Timing in Drosophila.

The central mechanisms coordinating growth and sexual maturation are well conserved across invertebrates and vertebrates. Although mutations in the gene encoding makorin RING finger protein 3 ( ) are associated with central precocious puberty in humans, a causal relationship has not been elucidated. Here, we examined the role of , a Drosophila ortholog of mammalian genes, in the regulation of developmental timing.

[Natural Transition Of Endemicity Of Malayan Flariasis In Inland Korea: Pattern Of Change In Microfilaria Rate Among Inhabitants Of Yongpung (Former Yongju) Area During The Period Of The Last Seven Years].

With a purpose to find out natural transition of endemicity of Malayan filariasis in inland Korea, a survey was conducted in June 1980 in Isan-Myeon of Yongpung-Gun (former Yongju-Gun) where an epidemiological investigation had been carried out in 1973 without any control activities such as chemotherapy. Five sample villages were surveyed for microfilaremia by 20 microliter night blood examination among inhabitants and the results of the surveys conducted in 1973 and 1980 were compared to determine natural transition of the endemicity of malayan filariasis during the period of the last 7 years. 1.

[Epidemiological conditions of Metagonimus yokogawai infection in Hadong Gun, Gyeongsang Nam Do].

An epidemiological investigation was conducted on Metagonimus yokogawai infection in Hadong Gun (County), Gyeongsang Nam Do, Korea, and following findings were obtained. 1. Overall prevalence rate of Metagonimus yokogawai infection was 29.