Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma.

Background: Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful evaluation of toxicities as well as overall clinical benefit. The purpose of this analysis was to examine common adverse events (AEs) reported in pivotal trials of romidepsin in relapsed/refractory PTCL or CTCL and to more clearly define the overall AE profile in these populations.

Freezing fingers syndrome, primary and secondary Raynaud's phenomenon: characteristic features with hand thermography.

The aim of the present study was to establish a thermographic model of healthy subjects' hands and compare it with a model of the hands of patients with freezing fingers syndrome, a group usually regarded as a healthy population. A further aim was to establish the thermographic parameters that distinguish primary Raynaud's phenomenon (RP) from secondary RP. The study was conducted on a group of 74 subjects, divided into 3 groups: patients with freezing hands symptoms (G1), those with primary RP (G2), and those with limited scleroderma (G3).

Molecular typing of Trichophyton rubrum clinical isolates from Poland.

The aim of this study was to investigate the intraspecific diversity of Trichophyton rubrum clinical isolates. Thirty clinical isolates of T. rubrum were selected for molecular typing by PCR amplification of two tandemly repetitive elements (TRS-1 and TRS-2) of the rDNA and randomly amplified polymorphic DNA (RAPD) analysis with primers designated 1 and 6.

Pachydermatous eosinophilic dermatitis.

A case is presented of a female Caucasian patient with chronic peripheral blood eosinophilia and unusual skin manifestations. Within a couple of years, the patient developed multiple hyperkeratotic and hyperpigmented papules and plaques all over the body, palmoplantar keratoderma, pachydermia of acral parts of the body, and generalized pruritus. Generalized lymphadenopathy appeared.

Multicentric reticulohistiocytosis with S100 protein positive staining: a case report.

Multicentric reticulohistiocytosis is a very rare systemic disease that affects skin, mucosa and joints. We reported a case of a woman with multicentric reticulohistiocytosis who presented typical skin syndromes and arthralgia. Immunohistochemical analysis showed positive staining for S100 protein, which was reported negative in the majority of previously presented cases.

Electrocardiographic evaluation in patients with systemic scleroderma and without clinically evident heart disease.

Background: In patients with systemic scleroderma (SSc), clinically evident cardiac involvement is recognized to be a poor prognostic factor. The aim of the study was to evaluate electrocardiographic changes, parameters of heart rate variability (HRV), and heart rate turbulence (HRT) in patients with SSc without evident symptoms of heart disease.

Methods: A group of 27 patients with SSc were subjected to standard electrocardiography (ECG) examination and 24-hour Holter monitoring.

Quality of life in patients suffering from seborrheic dermatitis: influence of age, gender and education level.

Seborrheic dermatitis is a common inflammatory skin condition occurring mostly on the face, scalp and chest. Despite its high frequency, the impact of seborrheic dermatitis on patients' quality of life (QoL) has not been studied well so far. The objectives of this study were to analyse how seborrheic dermatitis affects the patients' QoL and which socio-economic factors could modulate QoL in these patients.

IL-6 and IL-10 promoter gene polymorphisms in psoriasis vulgaris.

Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated.

IFN-gamma promoter gene polymorphism in psoriasis vulgaris.

This study was performed to investigate the association between interferon (IFN)-gamma single nucleotide polymorphism (SNP) and susceptibility for psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris (54 patients with type I psoriasis, 24 with type II psoriasis) and 74 healthy volunteers was investigated. IFN-gamma promoter gene SNP in position 874 was evaluated by polymerase chain reaction with sequence-specific primers (PCR-SSP) and the results were compared between a group of psoriatic patients, divided into early onset of psoriasis (type I) and late onset of psoriasis (type II) subgroups, and healthy control subjects.

TGF-beta(1) gene polymorphism in psoriasis vulgaris.

Overexpression of TGF-beta(1) has been implicated in the pathology of many inflammatory diseases, including psoriasis. This study was performed to investigate the association between TGF-beta(1) single nucleotide polymorphism and susceptibility for psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated.

A - 308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. No difference either between psoriasis type I and type II patients.

Background: Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions.

Factors influencing coexistence of toenail onychomycosis with tinea pedis and other dermatomycoses: a survey of 2761 patients.

Objective: To evaluate the prevalence and factors influencing the presence of concomitant dermatomycoses in patients with toenail onychomycosis.

Design: Prospective study based on a specially designed questionnaire completed by dermatologists.

Patients: A total of 2761 patients with toenail onychomycosis.

Severe acute generalized exanthematous pustulosis in a pregnant woman.

A 23-year-old woman was admitted to the Department of Dermatology 4 days postpartum with multiple disseminated pustules. A week earlier, she had received 500 mg of amoxicillin with 125 mg clavulanic acid for pharyngitis. After three doses, she noticed the first pustules appear on the chest and back, and the antibiotic treatment was discontinued.

Wavelet analysis of scaling properties of gastric electrical activity.

We present a novel approach to the analysis of fluctuations in human myoelectrical gastric activity measured noninvasively from the surface of the abdomen. The time intervals between successive maxima of the wavelet transformed quasi-periodic electrogastrographic waveform define the gastric rate variability (GRV) time series. By using the method of average wavelet coefficients, the statistical fluctuations in the GRV signal in healthy individuals are determined to scale in time.

[Adhesion of Candida to the obturator and oral mucosa as a cause of the presence of inflammation in patients treated surgically for neoplasia].

The aim of the investigation was to prove the relationship between Candida species, silicone and the oral mucosa as well as its effect on mutual reinfections of the mucosa and the obturator. Twenty-five patients with post-surgical prostheses in the maxilla were examined. All the prostheses had an obturator with the external part made of Mucopren silicone manufactured by Kettenbach, Germany.

[Diagnostic, prophylactic and therapeutic guidelines in patients with atopic dermatitis. Position paper by the task force of the National Specialists on Dermatology, Venereology and Allergology].

Treatment modalities of patients with atopic dermatitis (AD) are dependent on patient age, on the intensity of both skin symptoms and subjective signs of the disease i.e. itch and sleep disturbances, on the body surface involved with lesions, as well as on the type of sensitizing allergens.

Serum concentrations of transforming growth factor beta 1 in patients with psoriasis vulgaris.

Psoriasis is a common chronic cutaneous disease affecting 1-3% of general population. Its pathogenesis is not fully understood, but the involvement of several cytokines has clearly been established. The aim of the present study was to evaluate serum concentrations of transforming growth factor (TGF)-beta 1 in patients with psoriasis vulgaris and to correlate these concentrations with severity of psoriasis and several other clinical parameters.

Basal cell carcinoma on the eyelids: own experience.

Background: Basal cell carcinoma (BCC) is the most common skin malignancy. Eyelids constitute a special location of BCC because of the proximity of the eyeball.

Objective: This study was undertaken to evaluate the incidence of BCC located on the eyelids, to examine the clinical and histologic types of BCCs in this location, and to present some reconstructive techniques used in the treatment of BCC in palpebral region.

Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients.

Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls.