Publications by authors named "Eugenio Graceffo"
Thyroid hormone receptor alpha (THR) is a nuclear hormone receptor that binds triiodothyronine (T3) and acts as an important transcription factor in development, metabolism, and reproduction. The coding gene, , has two major splicing isoforms in mammals, and , which encode THR1 and THR1, respectively. The better characterized isoform, THR1, is a transcriptional stimulator of genes involved in cell metabolism and growth.
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- Thyroid hormone receptor alpha (THRα) is a crucial receptor that binds T3 and regulates important biological processes such as development, metabolism, and reproduction through its two main isoforms, THRα1 and THRα2.
- THRα1 promotes gene expression for cell metabolism and growth, while THRα2, which lacks the ligand-binding capability, is thought to inhibit the function of THRα1, making their ratio essential for proper gene regulation.
- The study utilized RNA-sequencing methods to analyze expression patterns of these isoforms in healthy human tissues and the developing brain, revealing a significant prevalence of THRα1 during various stages of brain development and in adult central nervous system tissues.