Tumor-Targeted Glutamine Metabolism Blocker Synergizes with TiO-Au Janus Nanoparticles for Enhanced Sono-Metabolic Antitumor Therapy.

Sonodynamic therapy (SDT) is a promising therapeutic modality known for its non-invasiveness, temporal-spatial controllability, and deeper tissue penetration. However, the SDT treatment efficacy is still hampered by the scarcity of ideal sonosensitizers and complex tumor microenvironment (TME). To address these challenges, a sono-metabolic nano-composite (TiO-Au@DON) using the metabolic reprogramming prodrugs of 6-Diazo-5-oxo-l-norleucine (DON) grafted on TiO-Au Janus nanoparticles (NPs) is fabricated.