Interaction of Salicylates and the Other Nonsteroidal Anti-Inflammatory Agents With Breast Cancer Endocrine Treatment: Systematic Review.

Despite advances in breast cancer treatment, mortality from breast cancer is still high. Undoubtedly, novel treatment strategies are needed for chemoprevention of high-risk women and for the treatment of receptor-negative breast cancer. An appealing strategy would be the combination of breast endocrine treatment with salicylates and the other nonsteroidal anti-inflammatory agents (NSAIDs).

Aspirin and NSAIDs for breast cancer chemoprevention.

Novel treatment strategies are needed for breast cancer chemoprevention. Tamoxifen is the only drug approved for the chemoprevention of estrogen receptor-positive breast cancer. However, to date, no treatment exists for the chemoprevention of estrogen receptor-negative breast cancer.

Green tea catechins: Proposed mechanisms of action in breast cancer focusing on the interplay between survival and apoptosis.

Recent data have shown strong chemopreventive and possibly cancer chemotherapeutic effects of green tea polyphenols against cancer. Despite advances in breast cancer treatment, mortality from breast cancer is still high. Undoubtedly novel treatment strategies are needed for chemoprevention of high risk women and for the treatment of receptor negative breast cancer.

Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies.

Catechins (flavan-3-oils) are the main flavonoids present in green tea. The potential cancer chemopreventive and therapeutic properties of green tea catechins have been the focus of research efforts in the last two decades. This systematic review aims to generate in vitro and in vivo data on the effect of green tea catechins on breast carcinogenesis.

Targeting oxidative stress response by green tea polyphenols: clinical implications.

Green tea polyphenols, the most interesting constituent of green tea leaves, have been shown to have both pro-oxidant and antioxidant properties. Both pro-oxidant and antioxidant properties are expected to contribute to modulation of oxidative stress response under ideal optimal dosage regimens. Exposure to a low concentration of a pro-oxidant prior to exposure to oxidative stress induces the expression of genes that code for proteins that induce adaptation in a subsequent oxidative stress.

Effect of laparoscopic surgery on oxidative stress response: systematic review.

This systematic review aimed to investigate: (a) the impact of laparoscopic surgery on oxidative stress (OS) and (b) the effect of laparoscopic surgery on OS in comparison with open surgery. Eligible trials were clinical trials or retrospective studies with at least 1 arm for laparoscopic surgery with measurements of at least 1 marker of OS or of antioxidant defenses. Twenty-nine trials fulfilled inclusion criteria.

Does pharmacodynamic interaction of nonenzymatic antioxidants modify response to antioxidant therapy in the process of atherosclerosis?

A discrepancy exists between clinical trials and epidemiological studies on the effect of antioxidants on cardiovascular disease. This discrepancy could be attributed to the lack of knowledge on the effect of interaction of exogenous antioxidant supplementation with one another or on the effect of interaction of exogenously administered antioxidant vitamins with endogenous ones. This study attempts a systematic review of available data on possible synergistic, additive, or antagonistic action of nonenzymatic antioxidants in atherosclerosis.

Recent patents on antibacterial, antifungal and antiviral properties of tea.

Teas have beneficial effects on human health including cardioprotective, anticarcinogenic, antibacterial, antiviral and antifungal activity. The precise antimicrobial spectrum of tea is difficult to be defined due to variation in the methods of testing that have been used. Antibacterial effects of tea have been demonstrated against a number of microorganisms including Staphylococcus aureus, Vibrio cholerae, Escherichia coli, Shigella spp.

Pharmacogenomics of breast cancer targeted therapy: focus on recent patents.

Adjuvant endocrine therapy as well as other forms of targeted therapy such as HER2 inhibitors and antiangiogenic agents reduce the risk of recurrence and improve survival among women with hormone receptor positive breast cancer. However, a significant percentage of women who receive targeted therapy as adjuvant or metastatic treatment do not benefit from this therapy, while a number of women who initially respond will eventually develop disease progression and relapse while on therapy. The observed variability in treatment response to targeted breast cancer treatment could be partly explained by pharmacogenomics.

Adherence to antihypertensive treatment: a critical factor for blood pressure control.

Background: To compare rates of blood pressure (BP) control with the level of adherence to antihypertensive treatment and factors influencing compliance in Greek patients.

Design: An observational cross-sectional study on 1000 consecutively treated hypertensive patients, admitted to a University department of general surgery in a Greek hospital.

Methods: Patients were interviewed by the same doctor using pre-coded questionnaires with questions on demographic data, health and treatment status.