Publications by authors named "Eugenia A Panova"
Article Synopsis
- mRNA-based therapies have gained popularity over the last decade, particularly highlighted by their role in mass COVID-19 vaccination, leading to further research into antiviral and anti-cancer vaccines and genetic treatments.
- Lipid nanoparticles (LNPs) are crucial for mRNA delivery, and adaptable LNP systems are needed to better control how mRNA is taken up and expressed in target cells.
- New cationic lipid formulations (2X3 and 2X7) have shown effective mRNA delivery in lab cells and live mice, demonstrating prolonged gene activity and localized expression in muscles, pointing to their potential for long-term therapeutic applications.
Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly simplifies any genetic engineering manipulations. Such antibodies have the ability to bind hard-to-reach antigenic epitopes through long parts of the variable chains, the third complementarity-determining regions (CDR3s).
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