Publications by authors named "Eugeni Turkin"
Article Synopsis
- Perchlozone (PCZ) is a new thiosemicarbazone drug approved for multidrug-resistant tuberculosis (MDR-TB) treatment in Russia and some other countries.
- The study aimed to explore genetic variations that cause PCZ resistance by using whole genome sequencing on bacterial isolates from patients undergoing treatment at a regional tuberculosis dispensary in Kaliningrad.
- Researchers found that certain mutations, including the frequent frameshift mutation 106 GA > G, often existed before treatment, highlighting the need to consider cross-resistance with other drugs like ethionamide and prothionamide in treatment regimens.
The Kaliningrad region is the westernmost part of the Russian Federation; it includes an enclave on the Baltic Sea inside the European Union separated from mainland Russia by Lithuania and Poland. The incidence of tuberculosis in Kaliningrad has shown a steady and dramatic increase from 83/100,000 in 2000 to 134/100,000 in 2006; the rate of multidrug-resistant tuberculosis (MDR-tuberculosis) in the Kaliningrad region was reported to be 30.5% among newly diagnosed tuberculosis patients.
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