Oral antimicrobial options for vancomycin-resistant isolates in urine culture.

Objectives: The present study aimed to investigate the susceptibility profiles of vancomycin-resistant isolates in urine culture to create an antibiogram to guide selection of oral antimicrobials in British Columbia (BC), Canada.

Methods: An audit was conducted on all urine cultures reported from January 1, 2021, to December 31, 2023, in LifeLabs BC microbiology laboratories. species in urine were routinely tested with ampicillin, ciprofloxacin, nitrofurantoin, tetracycline, and vancomycin.

Mixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass.

Acute leukemia with TCF3::ZNF384 is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B/myeloid). We report the first case of TCF3::ZNF384 mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated.

Finding significant pathogens in blood cultures in children: Should we set the timer to 36 hours?

Background: Knowledge of time to positivity (TTP) for blood cultures is useful to assess timing of discontinuation of empiric antimicrobials for suspected bacteremia with no focus.

Methods: An audit of positive blood cultures from the Children's Hospital of Eastern Ontario (CHEO) from November 1, 2019, to October 31, 2020, was performed to determine TTP, defined as the start of incubation to a positive signal from automated incubators.

Results: Three hundred seventy-six positive blood cultures were identified from 248 patients (average age: 6.

Answer to the Photo Quiz: Were those hyphae or pseudohyphae in blood culture?

Read the full article for the answer.

Use of Pulsed-Field Gel Electrophoresis to Determine the Source of Methicillin-Resistant Bacteremia.

Pulsed-field gel electrophoresis (PFGE) has historically been considered the gold standard in fingerprinting bacterial strains in epidemiological studies and outbreak investigations; little is known regarding its use in individual clinical cases. The current study detailed two clinical cases in which PFGE helped to determine the source of their methicillin-resistant (MRSA) bacteremia. Patient A was found to have MRSA bacteremia after trauma in her pelvic area.

A Case Series of Diarrheal Diseases Associated with .

To date, , , and are the three species generally agreed to be pathogenic in humans. However, there are a limited number of studies that suggest some of the "non-pathogenic" species may also cause infections. For instance, used to be known as an atypical strain until rhamnose biochemical testing was found to distinguish between these two species in the 1980s.

A Case-Control Study on the Association between Bacteriuria and Cystoscopy.

To date, there is only one published report of an outbreak of urinary tract infections by species after cystoscopy. Disinfection procedures for cystoscope have come into question. The current study aimed to determine the odds of developing bacteriuria after cystoscopy.

A Pregnant Patient With a Large Anterior Mediastinal Mass for Thymectomy Requiring One-Lung Anesthesia.

Anesthetic management for anterior mediastinal mass resection is often challenging. The main concern being that the tumor might, on reduction in muscle tone, cause circulatory and/or airway collapse. In the setting of pregnancy, the expected physiologic changes (eg, increased oxygen demand, decreased functional residual capacity, and aortocaval compression) may further increase the risks.

First case report of infective endocarditis associated with .

species are gram positive coryneforms generally considered as a contaminant when identified in gram stain of blood culture, especially when time-to-positivity is longer than 48 h. We encountered a case of infective endocarditis associated with bacteremia, which became positive after 48 h of incubation in three out of four bottles. The antimicrobial management is controversial as vancomycin is generally assumed to cover most gram positive bacilli, but our susceptibility result demonstrated minimum inhibitory concentration of 4 μg/mL of vancomycin, indicating non-susceptibility.