Deep vein thrombosis associated with a single dose of romiplostim in a high-risk patient.

Purpose: The case of a patient who developed thrombosis after receiving a single dose of romiplostim is reported.

Summary: A 63-year-old, 76-kg Caucasian man arrived at our clinic complaining of right-lower-extremity edema and redness. The patient had a complicated cardiac history, including two coronary artery bypass grafts and five percutaneous coronary interventions.

Pralatrexate: a novel synthetic antifolate for relapsed or refractory peripheral T-cell lymphoma and other potential uses.

Purpose: The pharmacology, pharmacokinetics, clinical trials, adverse effects, dosage, and economic considerations of pralatrexate (PDX) are reviewed.

Summary: Peripheral T-cell lymphoma (PTCL) comprises approximately 15-20% of all aggressive lymphomas and 5-10% of all non-Hodgkin's lymphomas. Advanced PTCL is often refractory to traditional first-line chemotherapy regimens.