Publications by authors named "Eugene J-M Thonar"
Article Synopsis
- The study compares the impacts of various bone morphogenetic proteins (BMPs) and Sox9 on the extracellular matrix accumulation by bovine anulus fibrosus (AF) cells through adenoviral-mediated overexpression.
- Findings show that several BMPs (specifically BMP-2, -3, -5, -7, -8, -12, -13, -14, and -15) and Sox9 significantly boost collagen and proteoglycan accumulation in AF cells compared to a control group.
- This research is the first systematic comparison of multiple growth factors in the AF, offering insights valuable for potential therapies targeting nucleus pulposus herniation and degenerative disc disease.
Objective: To evaluate the effects of oral salmon calcitonin (sCT) on Lequesne's algofunctional index scores and on biomarkers of joint metabolism in knee osteoarthritis.
Methods: In this randomized, double-blind trial, patients received either placebo (n = 18), 0.5 mg of sCT (n = 17), or 1 mg of sCT (n = 18) daily for 84 days.