Publications by authors named "Eugene Hsiao"

How common are penile amputations, and how are they treated?What key anatomic structures are involved?What are some technical pearls for a successful replantation?What are common complications, and how can they be prevented/treated?

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Article Synopsis
  • Hepatocellular carcinoma (HCC) is a major cause of cancer deaths, and Sorafenib was the only FDA-approved treatment for advanced cases until recently, highlighting the need for new therapies.
  • This study developed a zebrafish drug screening platform to compare two new drugs, 419S1 and 420S1, with Sorafenib, finding that all three have anti-angiogenesis properties but 419S1 resulted in lower toxicity to both the liver and embryos.
  • Ultimately, 419S1 and 420S1 showed better effectiveness in halting liver cancer growth compared to Sorafenib, suggesting the zebrafish model can aid in discovering safer and more effective treatments for HCC and personalized medicine
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Active pronation is important for many activities of daily living. Loss of median nerve function including pronation is a rare sequela of humerus fracture. Tendon transfers to restore pronation are reserved for the obstetrical brachial plexus palsy patient.

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Background: Composite tissue allotransplantation of hand, facial and other tissues is now a clinical reality. The terminology, treatment principles, drug combinations, dosage schedules and mechanisms of the immunosuppression medications on which contemporary transplant surgery is based are unfamiliar to plastic surgeons and most healthcare providers outside the field of transplantation medicine. With this in mind, the purpose of this manuscript is to provide plastic surgeons with a comprehensive and understandable review of key immunological principles relevant to composite tissue allotransplantation.

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