The impact of oral hypoglycemics and statins on outcomes in myelodysplastic syndromes.

Observational studies suggest an anti-neoplastic effect associated with statins, metformin, and dipeptidyl peptidase-4 inhibitors (DPP4i), while sulfonylureas may have a neutral or detrimental effect. We linked the Ontario subset of a prospective Canadian myelodysplastic syndromes (MDS) registry with provincial administrative databases. We assessed the impact of statin/oral hypoglycemic medication exposure on overall survival (OS) using Cox regression analysis, controlling for comorbidities and sociodemographic factors.

Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling.

To determine causes of apoptotic resistance, we analyzed 124 primary B cell NHL samples using BH3 profiling, a technique that measures the mitochondrial permeabilization upon exposure to synthetic BH3 peptides. Our cohort included samples from chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), high-grade B cell lymphoma with translocations in and (HGBL-DH), mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL). While a large number of our samples displayed appropriate responses to apoptosis-inducing peptides, pro-apoptotic functional defects, implicating BAX, BAK, BIM or BID, were seen in 32.

Marital status and age of systemic lupus erythematous diagnosis: the potential for differences related to sex and gender.

Objectives: Chronic rheumatic diseases can challenge social and family relationships. We compared marital status in patients with systemic lupus erythematous (SLE) with their general population counterparts, stratified by sex and age of SLE onset.

Methods: We performed a cross-sectional analysis of a cohort of 382 patients with SLE at our centre (349 females, 33 males).

Renal artery reconstruction and kidney autotransplantation for Takayasu arteritis-induced renal artery stenosis.

A young woman with Takayasu arteritis and complex renal artery stenosis in a solitary functional kidney underwent an ex vivo revascularization with autologous saphenous vein graft and renal autotransplantation. Before surgery, she had resistant hypertension and recurrent episodes of acute kidney injury. Two years later, her blood pressure is 123/77 mm Hg, and there have been no acute kidney injury episodes.