Publications by authors named "Eugene B Tsitrin"
Targeted delivery of liposomal nanocontainers to the peritumoral zone of glioma by means of monoclonal antibodies against GFAP and the extracellular loop of Cx43.
Vladimir P Chekhonin Vladimir P Baklaushev Gaukhar M Yusubalieva Anastasia E Belorusova Michael V Gulyaev Eugene B Tsitrin
Nanomedicine
January 2012
Article Synopsis
- Researchers studied PEGylated immunoliposomes using monoclonal antibodies against GFAP and connexin 43 to target gliomas in animal experiments.
- These immunoliposomes were labeled with two types of markers (fluorescent and paramagnetic) to visualize their distribution.
- The findings indicate that these targeted nanocarriers can effectively deliver drugs to areas surrounding high-grade gliomas, focusing on the peritumoral invasion zone.
Article Synopsis
- The study explored how well monoclonal antibodies targeting the E2 fragment of connexin 43 (Cx43) could identify glioma cells in animal models with brain tumors.
- Two types of labeled antibodies were injected into rats with gliomas, showing significant accumulation at the tumor site and less in other organs after 72 hours.
- The findings indicate that these antibodies can accurately visualize glioma cells and suggest their potential use for delivering drugs specifically to glioma invasion areas, highlighting their role in targeted cancer treatment.