Publications by authors named "Eugene A Zubkov"
Article Synopsis
- Inflammatory bowel diseases involve ongoing inflammation in the intestines and changes in gut microbiota, which can be influenced by outer membrane vesicles (OMVs) that contain polysaccharide A (PSA).
- The study used a mouse model of intestinal colitis induced by sodium dextran sulfate (DSS) and examined the effects of OMV treatment by assessing disease severity and gut tissue health through disease activity index (DAI) and histology.
- Results indicated that OMV treatment improved intestinal healing and altered microbiota composition, highlighting OMVs’ potential as both anti-inflammatory agents and facilitators of microbiota recovery.
Article Synopsis
- Inflammatory bowel diseases (IBD) are widespread but often show no symptoms early on, highlighting the need for effective, non-invasive diagnostic methods.
- This study proposes a technique to monitor IBD development by analyzing volatile organic compounds (VOCs) produced by gut microbiota using HS GC/MS during different inflammation stages in a rat model.
- Results showed significant changes in the metabolomic profile, particularly in short-chain fatty acids, during acute and remission phases of IBD, indicating potential biomarkers for early detection and monitoring of the disease.
Article Synopsis
- The LCGA-17 peptide is introduced as a new candidate for treating anxiety and depression, working through specific brain receptors and potentially enhancing GABA-A receptor activity.
- The study tested the effects of acute and chronic intranasal LCGA-17 on stress and anxiety in rats, using various behavioral tests that mimic symptoms of PTSD and depression.
- Results showed significant anxiolytic and antidepressant effects from LCGA-17, outperforming some existing treatments, and it also restored important neurotransmitter levels in the brain post-stress, suggesting its potential for rapid action in mental health treatment.
Willner's "chronic mild stress" (CMS) model is a globally recognized and most commonly used depression model. A depression model induced by ultrasonic exposure of variable frequencies has been created in our laboratory. This article compares two models of the depressive-like state according to three validity criteria.
View Article and Find Full Text PDFBackground: Previous studies have shown the development of emotional and motivational disorders, such as anxiety-depression-like disorders with increased aggression in adolescent and adult Wistar rats, occurs after neonatal exposure to the dipeptidyl peptidase-IV (DPP-IV, EC 3.4.14.
View Article and Find Full Text PDFSubclinical hypothyroidism is caused by thyroid hormone deficit and can lead to impairments in mood and cognition. In brain, supply with thyroxine (T4) is mediated by thyroid hormone transporters including the brain-specific anion transporter-1 (BSAT-1). In humans and rodents, BSAT-1 is expressed in brain microvessels and astrocytes.
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