Publications by authors named "Eugene A Albert"
Article Synopsis
- - Cholangiocarcinoma is a severe cancer with a low survival rate, often diagnosed too late for surgical treatment and usually managed with chemotherapy that only offers about a 12-month median survival.
- - A case study involving a 72-year-old man with aggressive metastatic cholangiocarcinoma showcases the use of personalized treatment through tyrosine kinase inhibitors (TKIs), starting with sorafenib, which stabilized his condition and improved quality of life for nearly 6 months before switching to Pazopanib.
- - The study highlights the potential benefits of tailoring TKI therapy based on genetic testing of the tumor, suggesting that personalized treatments can extend survival and enhance the patient's quality of life beyond typical chemotherapy outcomes.
Niches have traditionally been characterised as signalling microenvironments that allow stem cells to maintain their fate. This definition implicitly assumes that the various niche signals are integrated towards a binary fate decision between stemness and differentiation. However, observations in multiple systems have demonstrated that stem cell properties, such as proliferation and self-renewal, can be uncoupled at the level of niche signalling input, which is incompatible with this simplified view.
View Article and Find Full Text PDFPlatelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells (MSC) and fibroblasts. PDGF stimulates generation of hydrogen peroxide that is required for cell migration, but the sources and intracellular targets of H2O2 remain obscure. Here we demonstrate sustained live responses of H2O2 to PDGF and identify PKB/Akt, but not Erk1/2, as the target for redox regulation in cultured 3T3 fibroblasts and MSC.
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