A new fast electrophysiological response measured extracellularly in a mouse hippocampal brain slice.

In a hippocampal mouse brain slice the CA1 stratum radiatum field potential evoked by electrical stimulation of the Schaffer collaterals was used to analyze the very early responses. Parallel bipolar electrodes were utilized to lower the voltage induced by the stimulating current in the recording electrode, and to keep the induced voltage within the linear range of the headstage preamplifier and the recording amplifiers. When the stimulating and recording electrodes are in saline in the same plane and same depth, the shapes of the recorded voltage and stimulating current are similar.