Effects of succinic acid on dermal fibroblasts during cultivation under extremely hypoxic conditions.

Succinate is one of the most important raw materials in the energy-producing cycle, enabling a 'shortcut' route for ATP production via oxidative metabolism. Fumarate is produced from succinate by the oxygen-dependent succinate dehydrogenase. In this study we investigated the influence of different succinic acid concentrations on the process of cellular senescence under normal and hypoxic conditions.