Publications by authors named "Eue-Keun Choi"

Background: Atrial fibrillation (AF) is associated with increased risks of adverse events including stroke and all-cause death. Understanding the pattern of causes of death (COD) with the relative risks in patients with AF compared to the non-AF population is essential in planning optimal care for patients with AF. We aimed to analyze the COD and its relative risks in patients with AF, using a nationwide population-based cohort.

View Article and Find Full Text PDF

Background And Objectives: Evidence remains limited on the real-world prescription of very low-dose oral anticoagulation among frail patients with atrial fibrillation (AF). We described the practice patterns, effectiveness, and safety of very low-dose edoxaban (15 mg once daily).

Methods: Patients with AF prescribed edoxaban 15 mg once daily in 2 tertiary hospitals between 2016 and September 2022 were included.

View Article and Find Full Text PDF

Background And Objectives: Several real-world studies have been done in patients with nonvalvular atrial fibrillation (NVAF); however, information on its safety profile in patients with renal impairment is limited. XARENAL, a real-world study, aimed to prospectively investigate the safety profile of rivaroxaban in patients with NVAF with renal impairment (creatinine clearance [CrCl], 15-49 mL/min).

Methods: XARENAL is an observational single-arm cohort study in renal impairment NVAF patients.

View Article and Find Full Text PDF

Background: Atrial fibrillation (AF) may have different clinical features in its early phase.

Objective: The purpose of this study was to compare the characteristics and clinical outcomes of early-phase AF with later-phase AF using a large multicenter prospective registry (CODE-AF [COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation]).

Methods: Patients enrolled between June 2016 and March 2021 were divided into 2 groups based on AF duration: (1) newly diagnosed (AF duration ≤90 days); and (2) previously diagnosed (AF duration >90 days).

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the difficulty of obtaining ECGs in patients with paroxysmal supraventricular tachycardia and explores using deep learning to classify types of tachycardia based on sinus rhythm ECGs.
  • Utilizing a modified deep learning model on data from 833 patients with AVNRT and 346 with concealed AVRT, the study found that pre-training the model improved classification performance significantly.
  • The results indicate that while deep learning can help differentiate between AVNRT and concealed AVRT using sinus rhythm ECGs, the performance is still modest, suggesting room for further improvement in non-invasive diagnoses.
View Article and Find Full Text PDF

Feature attribution methods can visually highlight specific input regions containing influential aspects affecting a deep learning model's prediction. Recently, the use of feature attribution methods in electrocardiogram (ECG) classification has been sharply increasing, as they assist clinicians in understanding the model's decision-making process and assessing the model's reliability. However, a careful study to identify suitable methods for ECG datasets has been lacking, leading researchers to select methods without a thorough understanding of their appropriateness.

View Article and Find Full Text PDF

: Relatively little has been established about the association of rapid ventricular response (RVR) with further recurrence of atrial fibrillation (AF). This study investigated the impact of RVR on the recurrence of AF. : Data were obtained from a multicenter, prospective registry of non-valvular AF patients.

View Article and Find Full Text PDF

Background: The ideal long-term antithrombotic strategy for patients after successful catheter-based atrial fibrillation (AF) ablation is still uncertain. Presently, practices vary, and the advantages of oral anticoagulation (OAC) for the post-ablation population are not clearly established. To date, no randomized trials have addressed this therapeutic question.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers conducted a trial comparing edoxaban monotherapy with dual antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease to assess risks of stroke and other serious outcomes.
  • The study involved 1,040 patients, with results showing fewer primary-outcome events in those on edoxaban alone (6.8% vs. 16.2% for dual therapy), indicating it may be safer.
  • Although the incidence of major bleeding was higher in the dual therapy group (14.2% vs. 4.7%), the major ischemic events were similar for both treatment groups.
View Article and Find Full Text PDF

Aims: To investigate plasma apixaban concentrations and thrombin generation assay (TGA) parameters across different apixaban doses in atrial fibrillation patients who had dose-reduction criteria for apixaban.

Methods: This observational study included 374 patients (mean age 75.6 ± 7.

View Article and Find Full Text PDF

Although the adverse effects of long-term use of vitamin K oral anticoagulant (OAC), warfarin, on the coronary vasculature are well-established, it remains unknown whether nonvitamin K oral anticoagulants play a role in the attenuation of plaque progression and coronary calcification. This study aimed to compare the changes in atherosclerotic plaques and calcification of the coronary arteries in patients with atrial fibrillation (AF) treated with edoxaban and warfarin. A total of 150 OAC-naïve patients with AF and atherosclerotic lesions on coronary computed tomography angiography (CCTA) were enrolled and randomly assigned to the edoxaban or warfarin treatment groups.

View Article and Find Full Text PDF

Background: Data on off-label reduced dose risk among patients with atrial fibrillation (AF) who qualify for a single-dose reduction of apixaban is scarce.

Objectives: We prospectively assessed apixaban dosing and clinical characteristics in AF patients meeting a dose reduction criterion.

Methods: The multicentre, prospective cohort study, the efficAcy and Safety of aPixaban In REal-world practice in Korean frail patients with AF (ASPIRE), encompasses patients with AF who met the criteria for a single-dose reduction of apixaban and were given varying doses of apixaban, either the on-label standard dose or the off-label reduced dose.

View Article and Find Full Text PDF
Article Synopsis
  • Renal function is essential in determining the appropriate dosage of oral anticoagulants for atrial fibrillation patients and is linked to stroke and bleeding risks.
  • The study analyzed 5,126 AF patients with marginal renal function over two years, categorizing them into maintained, improved, and worsened renal function groups based on eGFR changes.
  • Results indicated that patients with worsening renal function faced significantly higher risks of major bleeding, end-stage renal disease, all-cause mortality, and overall adverse clinical outcomes compared to those who maintained their renal function.
View Article and Find Full Text PDF

The optimal anesthetic agent for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) and its impact on the recovery profiles remain uncertain. We compared the recovery and hemodynamic parameters between the remimazolam-flumazenil and propofol groups during RFCA. Patients were randomized into the remimazolam-flumazenil and propofol groups.

View Article and Find Full Text PDF

Background: Patients with hypertension are at a high risk of atrial fibrillation (AF). Recent research has indicated the varying effects of antihypertensive medications on developing AF.

Objectives: We investigated the relationship between different types of antihypertensive medications and the risk of AF occurrence.

View Article and Find Full Text PDF

Background: While treatment interruption of non-vitamin K antagonist oral anticoagulants (NOACs) for elective surgery or procedures among patients with atrial fibrillation (AF) is becoming more prevalent, there remains insufficient evidence regarding the optimal perioperative management of NOACs, particularly procedures with minor bleeding risks.

Objective: This study aims to evaluate the safety and effectiveness of a simplified, standardized protocol for perioperative management of direct factor Xa inhibitors in patients, with AF undergoing procedures associated with minor bleeding risk.

Methods: This multicenter, prospective single-arm registry study plans to enroll patients undergoing procedures with minor bleeding risk who were prescribed direct factor Xa inhibitors for AF.

View Article and Find Full Text PDF

Background: Although early rhythm control (ERC) in patients with atrial fibrillation (AF) reduces the risk of stroke, there is no evidence thus far on whether ERC reduces the risk of developing dementia in patients with AF and prior stroke.

Objectives: This study sought to evaluate whether ERC reduces the risk of developing dementia in patients with new-onset AF and prior stroke.

Methods: Using the Korean nationwide claims database, we identified patients with new-onset AF and prior stroke between 2010 and 2016.

View Article and Find Full Text PDF

Background: The association between alcohol consumption and the risk of sudden cardiac death and/or fatal ventricular arrhythmia remains controversial.

Objective: We analyzed the association between alcohol consumption, genetic traits for alcohol metabolism, and the risk of sudden cardiac death and/or fatal ventricular arrhythmia.

Methods: We identified 397,164 individuals enrolled between 2006 and 2010 from the UK Biobank database and followed them until 2021.

View Article and Find Full Text PDF

Background: There are limited data regarding the combined effect of early rhythm control (ERC) and healthy lifestyle (HLS) behaviors on the risk of ischemic stroke in patients with atrial fibrillation (AF).

Objectives: This study sought to evaluate how the combination of ERC and HLS behaviors affects the risk of ischemic stroke in patients with AF.

Methods: Using the Korean National Health Insurance database, we included patients with new-onset AF between 2009 and 2016 (n = 208,662).

View Article and Find Full Text PDF
Article Synopsis
  • Cryoablation is a safe and effective treatment for atrial fibrillation (AF), but its outcomes may vary by body mass index (BMI) in patients, especially in Asians.
  • In a study involving 2,648 patients, underweight individuals had a higher recurrence rate of AF after treatment compared to those with a normal BMI, along with a greater risk of complications like transient phrenic nerve palsy.
  • These findings suggest that underweight patients require special attention during and after cryoablation due to increased risks of both AF recurrence and procedural complications.
View Article and Find Full Text PDF

Background: Diabetes mellitus (DM) duration affects incident atrial fibrillation (AF) risk; the effect of physical activity on mitigating AF risk related to varying DM duration remains unknown. We assessed the effect of physical activity on incident AF in patients with DM with respect to known DM duration.

Methods: Patients with type 2 DM who underwent the Korean National Health Insurance Service health examination in 2015-2016 were grouped by DM duration: new onset and < 5, 5-9, and ≥ 10 years.

View Article and Find Full Text PDF

Background: Wearable electrocardiogram (ECG) monitoring devices are used worldwide. However, data on the diagnostic yield of an adhesive single-lead ECG patch (SEP) to detect premature ventricular complex (PVC) and the optimal duration of wearing an SEP for PVC burden assessment are limited.

Objective: We aimed to validate the diagnostic yield of an SEP (mobiCARE MC-100, Seers Technology) for PVC detection and evaluate the PVC burden variation recorded by the SEP over a 3-day monitoring period.

View Article and Find Full Text PDF