Publications by authors named "Eudy A"
Article Synopsis
- The Type 1 and 2 systemic lupus erythematosus (SLE) Model aims to capture all symptoms experienced by SLE patients and is based on prior qualitative research reflecting their lived experiences.
- A qualitative study involving 13 rheumatologists was conducted to gather their feedback on the model's relevance to their clinical practice, with most expressing approval and finding it helpful for treatment and patient education.
- While the model was generally well-received, some rheumatologists raised concerns about its potential to contribute to overdiagnosis of SLE, highlighting the need for further research on its effects on patient interactions and outcomes.
The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes.
Arthritis Care Res (Hoboken)
September 2024
Article Synopsis
- The study examines how both medical and personal readiness for pregnancy affect various aspects of maternal health in women with systemic lupus erythematosus (SLE).
- Medical readiness is linked to disease activity and pregnancy outcomes, while personal readiness correlates with a patient's perception of their disease and their mental health.
- The findings suggest that improving medical readiness prior to conception can enhance pregnancy outcomes, while addressing unplanned pregnancies may benefit maternal mental health.
Introduction: Medication nonadherence is common in systemic lupus erythematosus (SLE) and associated with morbidity and mortality. We explored the reliability of pharmacy data within the electronic medical record (EMR) to examine factors associated with nonadherence to SLE medications.
Methods: We included patients with SLE who were prescribed ≥1 SLE medication for ≥90 days.
Objective: There are limited data on the reproductive health of women with vasculitis. This study used a prospective, international vasculitis pregnancy registry to survey women during and after pregnancy.
Methods: The Vasculitis Pregnancy Registry (VPREG) is imbedded within the Vasculitis Patient-Powered Research Network, an international online research infrastructure.
Objective: Characterise the relationship between hydroxychloroquine (HCQ) blood levels and the number of missed doses, accounting for dosage, dose timing and the large variability in pharmacokinetics (PK) between patients.
Methods: We externally validated a published PK model and then conducted dosing simulations. We developed a virtual population of 1000 patients for each dosage across a range of body weights and PK variability.
Objectives: We sought to identify the impact of preeclampsia on infant and maternal health among women with rheumatic diseases.
Methods: A retrospective single-center cohort study was conducted to describe pregnancy and infant outcomes among women with systemic lupus erythematosus (SLE) with and without preeclampsia as compared to women with other rheumatic diseases with and without preeclampsia.
Results: We identified 263 singleton deliveries born to 226 individual mothers (mean age 31 years, 35% non-Hispanic Black).
Article Synopsis
- Type 2 systemic lupus erythematosus (SLE) symptoms like fatigue and brain fog negatively impact the health-related quality of life in lupus patients, and the study aimed to explore their relationship with Type 1 SLE activity and lupus nephritis (LN) severity.
- A cross-sectional analysis of 244 SLE patients revealed that 10% had active nephritis, while others had either historical or no nephritis, and those with active nephritis reported more severe Type 2 SLE symptoms than those with inactive nephritis.
- The findings indicate that while Type 2 SLE symptoms are prevalent, their intensity in patients with active nephritis may lessen as nephritis improves, and interestingly, non-neph
Objective: In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationship to inflammation is less clear. The objective of this study was to interview individuals living with SLE to determine the content and face validity of the Type 1 & 2 SLE model.
Methods: We conducted a qualitative study using semi-structured interviews with a purposeful sample of participants who met classification criteria for SLE.
Article Synopsis
- This study investigates the effects of pregnancy on the metabolism of azathioprine (AZA) and its metabolites in women with rheumatic diseases, focusing on 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine nucleotide (6-MMPN).
- It includes data from 37 pregnancies and 108 blood samples, finding stable levels of 6-TGN but elevated levels of 6-MMPN during pregnancy without associated liver issues.
- The research notes a potential link between metabolite levels, maternal disease activity, and improved neonatal outcomes, although the findings on significant changes in 6-TGN levels during pregnancy were inconclusive.
Objective: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to identify factors that enable adherence to immunosuppressive medications among patients with SLE from racial and ethnic minority groups.
View Article and Find Full Text PDFObjective: To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reported outcome (PRO) measure, through the lens of the model.
Methods: Patients completed PROMIS-29 and the polysymptomatic distress scale (PSD).
Article Synopsis
- - The study aimed to create and evaluate a new physician-reported measure called the Type 2 Physician Global Assessment (Type 2 PGA) to better assess type 2 symptoms of Systemic Lupus Erythematosus (SLE), like fatigue and brain fog, which are not well captured by existing measures.
- - Six rheumatologists collaborated to develop the Type 2 PGA, and its effectiveness was tested on data from 263 patients, showing strong reliability among different doctors scoring the same symptoms.
- - Results indicated that the Type 2 PGA correlates well with specific patient-reported issues, suggesting it could enhance patient care by highlighting important symptoms that usual assessments overlook.
Objective: Systemic lupus erythematosus (SLE) flares are associated with increased damage and decreased health-related quality of life. We hypothesized that there is discordance between physicians' and patients' views of SLE flare. In this study, we aimed to explore patient and physician descriptions of SLE flares.
View Article and Find Full Text PDFWomen with systemic lupus erythematosus (SLE) who get pregnant while SLE is active or while on teratogens have higher risk of poor pregnancy outcomes. The American College of Rheumatology (ACR) Reproductive Health Guidelines recommend women conceive when SLE is well controlled and treated with pregnancy-compatible medications. The Healthy Outcomes in Pregnancy with SLE Through Education of Providers (HOP-STEP) Intervention was created to ascertain pregnancy interest and contraceptive use followed by a personalized pregnancy prevention and/or planning discussion (https://www.
View Article and Find Full Text PDFObjective: Disparities in pregnancy outcomes among women with SLE remain understudied, with few available racially diverse datasets. We sought to identify disparities between Black and White women in pregnancy outcomes within academic institutions in the United States.
Methods: Using the Common Data Model electronic medical record (EMR)-based datasets within the Carolinas Collaborative, we identified women with pregnancy delivery data (2014-2019) and ≥1 SLE International Classification of Diseases 9 or 10 code (ICD9/10) code.
Paget's Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (GRK3) is an important negative regulator of G protein-coupled receptor (GPCR) signaling.
View Article and Find Full Text PDFArticle Synopsis
- A new model called the Type 1 and 2 SLE Model was created to classify the symptoms of Systemic Lupus Erythematosus (SLE), distinguishing between inflammatory symptoms (Type 1) and fatigue and cognitive issues (Type 2).
- In-depth interviews with 42 SLE patients revealed two patterns of Type 2 SLE: Intermittent, where symptoms improve when Type 1 is inactive, and Persistent, where symptoms remain constant regardless of Type 1 activity.
- The study highlights the importance of patient experiences, showing that understanding these patterns can help better address the diverse symptoms that SLE patients face.
Background/objectives: Anti-neutrophil cytoplasmic antibody-associated vasculitis has reported hospital mortality rates ranging between 10% and 20% with inadequate information regarding causes and outcomes of these hospitalizations. Characterization of outcomes in anti-neutrophil cytoplasmic antibody-associated vasculitis can improve patient care and prognostication following hospitalization.
Methods: A medical records review of all hospitalizations between October 1, 2015, and December 31, 2018, of adults with granulomatosis with polyangiitis or microscopic polyangiitis at a single academic medical center was performed.
Objective: To character the molecular landscape of patients with type 1 and type 2 SLE by analysing gene expression profiles from peripheral blood.
Methods: Full transcriptomic RNA sequencing was carried out on whole blood samples from 18 subjects with SLE selected by the presence of manifestations typical of type 1 and type 2 SLE. The top 5000 row variance genes were analysed by Multiscale Embedded Gene Co-expression Network Analysis to generate gene co-expression modules that were functionally annotated and correlated with various demographic traits, clinical features and laboratory measures.
Article Synopsis
- - The study aimed to address medication nonadherence in patients with systemic lupus erythematosus (SLE) by refining and validating the DOSE-Nonadherence tool, which assesses both the extent and reasons for nonadherence.
- - Patient feedback and rheumatologist input helped modify the tool, and results showed good reliability and validity compared to other adherence measures, identifying nearly half of participants as nonadherent.
- - Common barriers to adherence included forgetfulness, physical fatigue, and "pill fatigue," indicating areas for potential intervention to improve medication adherence in SLE patients.
Article Synopsis
- Medication nonadherence is a significant issue for patients with systemic lupus erythematosus (SLE), particularly among underrepresented racial minorities who face more severe disease manifestations.* -
- A study found that 48% of 77 patients with SLE had persistent nonadherence to their medication, with trends showing this group was younger, more likely to be Black, and faced economic challenges.* -
- To improve adherence, the study suggests enhancing patient-provider communication and building patient self-efficacy, particularly targeting younger Black patients with lower incomes.*
Complete Genome Sequence of Bacteriophage Eula, Isolated on Microbacterium foliorum.
Microbiol Resour Announc
October 2022
Eula is a lytic microbacteriophage extracted from a soil sample collected in Statesville, NC, and isolated on Microbacterium foliorum NRRL B-24224. The Eula double-stranded DNA genome is 41,379 bp, with 69 predicted protein-coding genes and 1 tRNA. Based on gene content similarity, Eula was assigned to bacteriophage cluster EB.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated the link between lupus nephritis (LN) and negative pregnancy outcomes in pregnant women diagnosed with systemic lupus erythematosus (SLE).
- - Data from three cohorts consisting of 393 women was analyzed, revealing that those with a history of LN experienced higher chances of fetal loss and preeclampsia compared to those without LN.
- - Women with active nephritis had even greater odds of adverse pregnancy outcomes, indicating that both a history of LN and active nephritis significantly impact pregnancy health.
Arthritis is a leading cause of disability in adults, which can be intensely incapacitating. The location and intensity of the pain is both subjective and challenging to manage. Consequently, patient-directed delivery of anti-inflammatories is an essential component of future therapeutic strategies for the management of this disorder.
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