Regulation of contractility of cultured human endometrial stromal cells by tumor necrosis factor-alpha.

Objective: The aim of this study is to evaluate the involvement of tumor necrosis factor (TNF)-alpha in endometrial tissue remodeling during the perimenstrual period.

Study Design: Human endometrial stromal cells (ESCs) were isolated from eight premenopausal patients in the late secretory phase. The effects of TNF-alpha on the contractility of cultured ESCs were investigated by collagen gel contraction assay.