Publications by authors named "Etienne Poiraud"

Article Synopsis
  • BNC210 is a special type of medicine that helps reduce anxiety without making people feel sleepy or affecting their movement.
  • Researchers tested it in mice to see how it worked, finding it calmed them down without causing side effects like sedation or memory problems.
  • BNC210 mainly affects a specific receptor in the brain, suggesting it could be a safer option for treating anxiety compared to other medicines available today.
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Positive allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. Type I PAMs amplify peak channel response to acetylcholine but do not appear to influence channel desensitization kinetics, whereas Type II PAMs both increase channel response and delay receptor desensitization. Both Type I and Type II PAMs are reported in literature, but there are limited reports describing their structure-kinetic profile relationships.

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There is a growing body of evidence pointing to the pivotal role of alpha-7 nicotinic acetylcholine receptor (α7 nAchR) dysfunction in cognitive disorders such as Alzheimer's disease or schizophrenia. This study was undertaken to establish and characterize an in vivo model for cognitive disorder secondary to the blockade of α7 nAChR by its specific antagonist, methyllycaconitine (MLA). The results show that MLA elicited cognitive dysfunction as assessed by reduced spontaneous alternation of mice in the T-maze.

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