Repurposing fluvoxamine as an inhibitor for NUDT5 in breast cancer cell: an in silico and in vitro study.

Unlabelled: Drug repurposing is necessary to accelerate drug discovery and meet the drug needs. This study investigated the possibility of using fluvoxamine to inhibit the cellular metabolizing enzyme NUDT5 in breast cancer. Computational and experimental techniques were used to evaluate the structural flexibility, binding stability, and chemical reactivity of the drugs.

Recent advancements in carbon/metal-based nano-catalysts for the reduction of CO to value-added products.

Due to the increased human activities in burning of fossil fuels and deforestation, the CO level in the atmosphere gets increased up to 415 ppm; although it is an essential component for plant growth, an increased level of CO in the atmosphere leads to global warming and catastrophic climate change. Various conventional methods are used to capture and utilize CO, among that a feasible and eco-friendly technique for creating value-added products is the CORR. Photochemical, electrochemical, thermochemical, and biochemical approaches can be used to decrease the level of CO in the atmosphere.

Ionic liquid-assisted pretreatment of lignocellulosic biomass using purified Streptomyces MS2A cellulase for bioethanol production.

In recent years, the process of producing bioethanol from lignocellulosic biomass through biorefining has become increasingly important. However, to obtain a high yield of ethanol, the complex structures in the feedstock must be broken down into simple sugars. A cost-effective and innovative method for achieving this is ionic liquid pre-treatment, which is widely used to efficiently hydrolyze the lignocellulosic material.

Graphene materials in pollution trace detection and environmental improvement.

Water scarcity is a pressing issue experienced in numerous countries and is expected to become increasingly critical in the future. Anthropogenic activities such as mining, agriculture, industries, and domestic waste discharge toxic contaminants into natural water bodies, causing pollution. Addressing these environmental crises requires tackling the challenge of removing pollutants from water.

A novel approach to environmental pollution management/remediation techniques using derived advanced materials.

The carbon dioxide (CO) crisis is one of the world's most urgent issues. Meeting the worldwide targets set for CO capture and storage (CCS) is crucial. Because it may significantly reduce energy consumption compared to traditional amine-based adsorption capture, adsorption dependant CO capture is regarded as one of the most hopeful techniques in this paradigm.

Genomic analysis of lignocellulolytic enzyme producing novel Streptomyces sp.MS2A for the bioethanol applications.

The conversion of lignocellulosic waste to energy offers a cost-effective biofuel. The current study discusses the utilization of cellulose in rice husks by lichen-associated Streptomyces sp. MS2A via carbohydrate metabolism.

A comprehensive review on strategic study of cellulase producing marine actinobacteria for biofuel applications.

Every year, 180 billion tonnes of cellulose are produced by plants as waste biomass after the cultivation of the desired product. One of the smart and effective ways to utilize this biomass rather than burn it is to utilize the biomass to adequately meet the energy needs with the help of microbial cellulase that can catalytically convert the cellulose into simple sugar units. Marine actinobacteria is one of the plentiful gram-positive bacteria known for its industrial application as it can produce multienzyme cellulase with high thermal tolerance, pH stability and high resistant towards metal ions and salt concentration, along with other antimicrobial properties.

A systematic review of recent trends in research on therapeutically significant L-asparaginase and acute lymphoblastic leukemia.

L-asparaginases are mostly obtained from bacterial sources for their application in the therapy and food industry. Bacterial L-asparaginases are employed in the treatment of Acute Lymphoblastic Leukemia (ALL) and its subtypes, a type of blood and bone marrow cancer that results in the overproduction of immature blood cells. It also plays a role in the food industry in reducing the acrylamide formed during baking, roasting, and frying starchy foods.

Hydrothermally constructed AgWO-rGO nanocomposites as an electrode enhancer for ultrasensitive electrochemical detection of hazardous herbicide crisquat.

The advancements in electrode materials with high efficiency has been prioritized to effectively monitor the presence of harmful pesticides concerning the environment. In such a way, we hydrothermally constructed a hybrid AgWO-rGO nanocomposites for the rapid electrochemical detection of crisquat (CQT). The structural, compositional, morphological and topographical characterization for AgWO-rGO nanocomposites is thoroughly performed to understand its electrocatalytic properties.

Fabricating BiOI nanostructures armed catalytic strips for selective electrochemical and SERS detection of pesticide in polluted water.

We have constructed a dual mode catalytic strip equipped with 2D BiOI nanostructures and deployed for dual mode detection sensing of hazardous trichlorophenol (TCP). Synthesized BiOI nanostructures are investigated for its crystal architecture, morphology and chemical composition. The BiOI are loaded onto the catalytic strips with the assistance of gravity offered drying process.

Biogenic Synthesis of Iron Oxide Nanoparticles Using : Adsorption of Hexavalent Chromium from Aqueous Solution and In Vitro Cytotoxicity Analysis.

The biological synthesis of nanoparticles is emerging as a potential method for nanoparticle synthesis due to its non-toxicity and simplicity. In the present study, a bacterium resistant to heavy metals was isolated from a metal-contaminated site and we aimed to report the synthesis of FeO nanoparticles via co-precipitation using bacterial exopolysaccharides (EPS) derived from _RMSN6 strains. A three-variable Box-Behnken design was used for determining the optimal conditions of the FeO NPs synthesis process.

Incorporation of SiO functionalized gCN sheets with TiO nanoparticles to enhance the anticorrosion performance of metal specimens in aggressive Cl environment.

Nowadays, carbon-based nano-structured materials are widely preferred for composite coating as anti-corrosive reinforcement mainly due to its enhanced physical, chemical and mechanical properties. Herein we develop highly efficient Graphitic carbon nitride-Silica-Titania (gCN/SiO/TiO) ternary nanocomposite are synthesized and it is used as a nanofillers in the corrosive protection layer on the proposed metal specimen (i.e.

Influence of 2D template-assisted (SBA-15) metal oxide CoO for pseudocapacitive and dye degradation application.

Cobalt oxide (CoO) is a low-cost material exhibiting excellent physicochemical and photocatalytic properties indicating its potential use for next-generation eco-friendly energy storage and photocatalytic degradation applications. In this study, CoO nanoarcs were synthesized using SBA-15 as a template by microwave-assisted method to form an S15/m-CoO product. Characterization was done by low and wide-angle X-Ray diffraction, and Fourier transformed infra-red spectroscopic studies confirming the presence of S15/m-CoO.

Synthesis of recyclable GO/Cu(BTC)/FeO hybrid nanocomposites with enhanced photocatalytic degradation of aflatoxin B1.

This study evaluated the photocatalytic performance of the activated carbon assisted GO/Cu(BTC)/FeO photocatalyst for aflatoxin B1 (AFB1) degradation under ultraviolet light. The nanocomposite was characterized by Fourier transform infrared spectrometry (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and nitrogen adsorption-desorption. The numerous factors influencing the degradation efficiency of AFB1 including catalyst dose, pH importance, and contact time were also probed.

Encapsulation of Purified Pediocin of Pediococcus pentosaceus into Liposome Based Nanovesicles and its Antilisterial Effect.

Aims: To encapsulate a purified bacteriocin into a nanovesicles and check its antibacterial effect.

Background: Although the use of nano-encapsulated bacteriocins in food matrices is poorly reported, encapsulated nisin can reduce L. monocytogenes counts in whole and skimmed milk and in soft cheese.

Immobilization of cellulase enzymes on nano and micro-materials for breakdown of cellulose for biofuel production-a narrative review.

Cellulose is a very abundant polymer that is found in nature. Cellulose has been used as a raw material for production of biofuels for many years. However, there are multiple processing steps that are required so that cellulose can be used as a raw material for biofuel production.

Synthesis of a copper (II) metal-organic framework for photocatalytic degradation of rhodamine B dye in water.

The Cu(II) metal-organic frameworks (MOFs) based on 1,3,5-benzenetricarboxylic acid (Cu(BTC)) was synthesized by the hydrothermal method. The synthesized Cu(BTC) exhibited pyramid-shaped morphology and showing an average specific area of 32.16 m g.

Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity.

(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has been to understand the molecular pathways that play significant roles in diabesity. In this study, we aimed to investigate the genetic links between diabetes and obesity in diabetic individuals and highlight the role(s) of shared genes in individuals with diabesity.

Toxicity Analysis of Recombinant L-asparaginase I and II in Zebrafish.

L-asparaginases are extensively applied in the treatment of Acute Lymphoblastic Leukemia (ALL). The treatment regime of ALL consists of asparaginase from or . The survival rate post-chemotherapy has increased to < 90% in recent years.

Immobilization of Cu(btc) on graphene oxide-chitosan hybrid composite for the adsorption and photocatalytic degradation of methylene blue.

The graphene oxide (GO)-based materials are appealing channels for water treatment, their separation from water for recycle remains a task. The Cu(btc) (btc = benzene-1,3,5-tricarboxylic acid) metal organic framework (MOF) was covalently immobilized onto chitosan (CS)/graphene oxide (GO) to form a catalyst material, which was subjected to characterization by XRD, FTIR, SEM, TEM, BET, and UV-vis diffusive reflectance spectra. MOFs are permeable crystalline compounds consisting of metal ions and polyfunctional organic ligands.

Nattokinase: an updated critical review on challenges and perspectives.

Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT is a well studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy.

Purification, biochemical, and thermal properties of fibrinolytic enzyme secreted by Bacillus cereus SRM-001.

The discovery of microbial fibrinolytic enzymes is essential to treat cardiovascular diseases. This study reports the discovery of a fibrinolytic enzyme secreted by Bacillus cereus SRM-001, a microorganism isolated from the soil of a chicken waste-dump yard. The B.