Assessment of the efficacy of field and laboratory methods for the detection of Tropilaelaps spp.

Tropilaelaps spp. are invasive mites that cause severe disease in Apis mellifera colonies. The UK has deployed an elaborate surveillance system that seeks to detect these mites early in any invasion to allow the best opportunity to eradicate any incursion.

Discovery of Novel UDP--Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against .

This study describes a novel series of UDP--acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of LpxA with no activity against LpxA. The biochemical potency of the series was optimized through an X-ray crystallography-supported medicinal chemistry program, resulting in compounds with nanomolar activity against LpxA (best half-maximal inhibitory concentration (IC) <5 nM) and cellular activity against (best minimal inhibitory concentration (MIC) of 4 μg/mL).

Integral correlation for uneven and differently sampled data, and its application to the Law Dome Antarctic climate record.

We present a new simple and efficient method for correlation of unevenly and differently sampled data. This new method overcomes problems with other methods for correlation with non-uniform sampling and is an easy modification to existing correlation based codes. To demonstrate the usefulness of this new method to real-world examples, we apply the method with good success to two glaciological examples to map the ages from a well-dated ice core to a nearby core, and by tracing isochronous layers within the ice sheet measured from ice-penetrating radar between the two ice core sites.

Preindustrial CH indicates greater anthropogenic fossil CH emissions.

Atmospheric methane (CH) is a potent greenhouse gas, and its mole fraction has more than doubled since the preindustrial era. Fossil fuel extraction and use are among the largest anthropogenic sources of CH emissions, but the precise magnitude of these contributions is a subject of debate. Carbon-14 in CH (CH) can be used to distinguish between fossil (C-free) CH emissions and contemporaneous biogenic sources; however, poorly constrained direct CH emissions from nuclear reactors have complicated this approach since the middle of the 20th century.

Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica.

The future response of the Antarctic ice sheet to rising temperatures remains highly uncertain. A useful period for assessing the sensitivity of Antarctica to warming is the Last Interglacial (LIG) (129 to 116 ky), which experienced warmer polar temperatures and higher global mean sea level (GMSL) (+6 to 9 m) relative to present day. LIG sea level cannot be fully explained by Greenland Ice Sheet melt (∼2 m), ocean thermal expansion, and melting mountain glaciers (∼1 m), suggesting substantial Antarctic mass loss was initiated by warming of Southern Ocean waters, resulting from a weakening Atlantic meridional overturning circulation in response to North Atlantic surface freshening.

An Assessment of the Clinical Accuracy of Ultrasound in Diagnosing Cirrhosis in the Absence of Portal Hypertension.

Ultrasound is an invaluable tool for the diagnosis of hepatocellular carcinoma and portal hypertension. However, the accuracy of ultrasound in diagnosing cirrhosis in the absence of portal hypertension has not been well studied. Using the specific terms cirrhosis or nodular(ity), a retrospective evaluation was conducted on abdominal ultrasounds performed between 2008 and 2013.

Overestimate of committed warming.

Palaeoclimate variations are an essential component in constraining future projections of climate change as a function of increasing anthropogenic greenhouse gases. The Earth System Sensitivity (ESS) describes the multi-millennial response of Earth (in terms of global mean temperature) to a doubling of CO concentrations. A recent study used a correlation of inferred temperatures and radiative forcing from greenhouse gases over the past 800,000 years to estimate the ESS from present day CO is about 9°C, and to imply a long-term commitment of 3–7°C even if greenhouse gas levels remain at present-day concentrations.

Acceptance of a pre-visit intervention to engage teens in pediatric asthma visits.

Objective: The objectives of this study were to: (a) describe teen feedback on an asthma question prompt list/video intervention designed to motivate teens to be more engaged during visits and (b) examine teen demographics associated with teen acceptance of the intervention.

Methods: Two hundred and fifty-nine teens ages 11 to 17 with persistent asthma were enrolled into a randomized, controlled trial and assigned to either a standard care or an intervention group where they watched an educational video with their parents and received a prompt list to complete before visits. Teens were interviewed after visits.

Sonography Predicts Liver Steatosis in Patients With Chronic Hepatitis B.

Objectives: Liver inflammation and fibrosis may impair the ability of sonography to identify steatosis. We determined the accuracy of sonography in grading steatosis in patients with chronic hepatitis B compared to liver biopsy.

Methods: We conducted was a single-center retrospective study of all nontransplanted patients with chronic hepatitis B undergoing sonography and liver biopsy between 2004 and 2014 (n = 109).

Antarctic ice sheet discharge driven by atmosphere-ocean feedbacks at the Last Glacial Termination.

Reconstructing the dynamic response of the Antarctic ice sheets to warming during the Last Glacial Termination (LGT; 18,000-11,650 yrs ago) allows us to disentangle ice-climate feedbacks that are key to improving future projections. Whilst the sequence of events during this period is reasonably well-known, relatively poor chronological control has precluded precise alignment of ice, atmospheric and marine records, making it difficult to assess relationships between Antarctic ice-sheet (AIS) dynamics, climate change and sea level. Here we present results from a highly-resolved 'horizontal ice core' from the Weddell Sea Embayment, which records millennial-scale AIS dynamics across this extensive region.

The development of an educational video to motivate teens with asthma to be more involved during medical visits and to improve medication adherence.

Objectives: Our objective was to develop a series of short educational videos for teens and parents to watch before pediatric visits to motivate teens to be more actively involved during their visits.

Methods: The development of the short educational videos was theoretically guided by Social Cognitive Theory. First we conducted four focus groups with teens (ages 11 to 17) with asthma, four focus groups with the teens' parents, and seven focus groups with pediatric providers from four clinics.

Safe storage and effective monitoring of CO2 in depleted gas fields.

Carbon capture and storage (CCS) is vital to reduce CO(2) emissions to the atmosphere, potentially providing 20% of the needed reductions in global emissions. Research and demonstration projects are important to increase scientific understanding of CCS, and making processes and results widely available helps to reduce public concerns, which may otherwise block this technology. The Otway Project has provided verification of the underlying science of CO(2) storage in a depleted gas field, and shows that the support of all stakeholders can be earned and retained.

14CH4 measurements in Greenland ice: investigating last glacial termination CH4 sources.

The cause of a large increase of atmospheric methane concentration during the Younger Dryas-Preboreal abrupt climatic transition (approximately 11,600 years ago) has been the subject of much debate. The carbon-14 (14C) content of methane (14CH4) should distinguish between wetland and clathrate contributions to this increase. We present measurements of 14CH4 in glacial ice, targeting this transition, performed by using ice samples obtained from an ablation site in west Greenland.

A comment on the quantitative significance of aerobic methane release by plants.

A recent study by Keppler et al. (2006; Nature 439, 187-191) demonstrated CH emission from living and dead plant tissues under aerobic conditions. This work included some calculations to extrapolate the findings from the laboratory to the global scale and led various commentators to question the value of planting trees as a greenhouse mitigation option.

Unexpected changes to the global methane budget over the past 2000 years.

We report a 2000-year Antarctic ice-core record of stable carbon isotope measurements in atmospheric methane (delta13CH4). Large delta13CH4 variations indicate that the methane budget varied unexpectedly during the late preindustrial Holocene (circa 0 to 1700 A.D.

Sustainability, survivability, and the paradox of New Orleans.

Some precepts of the urban sustainability movement derive from the premise that economic expansion, population growth, and physical sprawl lead to a decline in quality of life, ecological damage, and eventual unsustainability. But what about cities that are failing-losing population, losing investment, losing infrastructure, even losing land? This article challenges conventional sustainability concepts, usually derived from the experiences of ascending cities, with the notion of survivability that confronts declining cities. Should troubled cities, such as New Orleans, located on the eroding Gulf of Mexico coastal region of the state of Louisiana, be held to different sustainability standards? Could urban expansion, in some cases, actually stem environmental degradation and enhance survivability?

Number of unowned free-roaming cats in a college community in the southern United States and characteristics of community residents who feed them.

Objective: To estimate the number of unowned free-roaming cats in a college community in the southern United States and identify the characteristics of community residents who feed these cats.

Design: Cross-sectional, random-digit telephone survey.

Sample Population: 587 households in Alachua County, Florida, surveyed between March 1 and May 10, 1999.