Publications by authors named "Ethel Mwewa"
Cancers (Basel)
November 2023
Article Synopsis
- The spread of tumor cells to essential organs significantly contributes to cancer-related deaths.
- This process, known as metastasis, complicates the treatment and management of various cancers.
- Understanding the mechanisms behind this spread is crucial for developing better therapies to improve patient outcomes.
Article Synopsis
- - The study investigates the differences in cancer drivers between primary and metastatic breast cancer using genetic techniques in female mice, focusing on mutations involving the Rb gene, which is often inactive in this type of cancer.
- - Researchers identified specific gene insertion sites (gCIS) that are linked to either primary tumors, metastases, or both, highlighting significant networks related to cancer progression, including a shared MET-RAS network and additional pathways for metastatic cancer.
- - Analysis of human clinical data reveals that certain genetic factors are more prevalent in primary tumors or metastases, suggesting targeted treatments that inhibit specific signaling pathways (like RB1, MET, and RHO) could help block tumor cell migration and improve outcomes for metastatic breast cancer patients.
