Publications by authors named "Ethan Tietze"
Article Synopsis
- Primary human trophoblast stem cells (TSCs) and those derived from human pluripotent stem cells (hPSCs) can be modeled in the lab, but how hPSCs differentiate into TSCs is not well understood.
- This study shows that a specific primed pluripotent state can produce TSCs by activating certain pathways (like EGF and WNT) and inhibiting others (like TGFβ and ROCK), all without adding BMP4, referred to as the TS condition.
- The researchers found that the TSCs generated under TS conditions can proliferate extensively and closely resemble first-trimester placental cells, suggesting that primed hPSCs can differentiate into TSCs through various
In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder. The fibroblasts were reprogrammed into iPS cells using episomal vectors carrying OCT3/4, SOX2, KLF4, L-Myc, LIN28 and shRNA-p53. All iPS cell lines showed the same genotype with parental postmortem brain tissues, expressed pluripotency markers, and exhibited the differentiation potency into three embryonic germ layers.
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