Publications by authors named "Ethan Thibault"
Article Synopsis
- Homeostasis of the endoplasmic reticulum (ER) is vital for growth and stress responses, with imbalances potentially leading to ER stress, which can trigger either protective or destructive cellular pathways.
- Understanding how cells make fate decisions during ER stress is important for improving crop development and offers insights into related diseases in animals.
- Post-translational modifications (PTMs) of proteins are crucial in influencing these cell-fate decisions during ER stress, and the review highlights areas for future research to discover more PTMs involved in managing ER stress.
Excessive accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress, which is an underlying cause of major crop losses and devastating human conditions. ER proteostasis surveillance is mediated by the conserved master regulator of the unfolded protein response (UPR), Inositol Requiring Enzyme 1 (IRE1), which determines cell fate by controlling pro-life and pro-death outcomes through as yet largely unknown mechanisms. Here we report that Arabidopsis IRE1 determines cell fate in ER stress by balancing the ubiquitin-proteasome system (UPS) and UPR through the plant-unique E3 ligase, PHOSPHATASE TYPE 2CA (PP2CA)-INTERACTING RING FINGER PROTEIN 1 (PIR1).
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- Boreal and northern temperate forest trees, like Populus balsamifera, have specific dormancy mechanisms that help them transition from winter to spring by requiring a certain amount of chilling degree days (CDD) before they start to grow again.
- A study found that the duration of chilling significantly affects the timing of bud flush, with southern tree genotypes needing more growing degree days (GDD) to flush compared to northern ones, indicating a latitudinal variation in bud flush timing.
- The results highlight how increased chilling reduces the GDD needed for bud flush and suggest that tree species have adapted their chilling requirements to avoid premature growth during warmer midwinter periods, showing important interactions between
Understanding the factors influencing the current distribution of genetic diversity across a species range is one of the main questions of evolutionary biology, especially given the increasing threat to biodiversity posed by climate change. Historical demographic processes such as population expansion or bottlenecks and decline are known to exert a predominant influence on past and current levels of genetic diversity, and revealing this demo-genetic history can have immediate conservation implications. We used a whole-exome capture sequencing approach to analyze polymorphism across the gene space of red spruce ( Sarg.
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