Robotic Assisted Cleft Palate Repair Using Novel 3 mm Tools: A Reachability and Collision Analysis.

Objective: Cleft palate repair is technically challenging: visualization is reduced, delicate dissection is required, and instrument reachability is limited within the infant oral cavity using standard instruments. A 3 mm diameter pin-jointed wristed tool was developed that couples to a da Vinci Research Kit (dVRK) to perform infant cleft palate surgery.

Methods: A reachability simulation analysis was performed to determine the number of collisions (tool-tool and tool-cavity) for tool tip positions within the oral cavity and the impact of dVRK trocar height.

Visualizing Ferroelectric Uniformity of HfZrO Films Using X-ray Mapping.

HfZrO (HZO) is a complementary metal-oxide-semiconductor (CMOS)-compatible ferroelectric (FE) material with considerable potential for negative capacitance field-effect transistors, ferroelectric memory, and capacitors. At present, however, the deployment of HZO in CMOS integrated circuit (IC) technologies has stalled due to issues related to FE uniformity. Spatially mapping the FE distribution is one approach to facilitating the optimization of HZO thin films.

Effect of early adverse events resulting in ado-trastuzumab emtansine dose adjustments on survival outcomes of HER2+ advanced breast cancer patients.

Purpose: Ado-trastuzumab emtansine (T-DM1) treatment in HER2+ advanced breast cancer patients is generally well tolerated, but when adverse events occur dose adjustments may be required. This study evaluated the impact of early adverse events requiring T-DM1 dose interruptions or reductions on overall survival (OS) and progression-free survival (PFS) in HER2+ advanced metastatic breast cancer patients in the clinical trials EMILIA and TH3RESA.

Patients And Methods: The study included 893 participants initiated on T-DM1 treatment.