Average Scleral Lens Replacement Period at a Tertiary Care Hospital.

Objective: To evaluate the average scleral lens replacement period at a tertiary care hospital.

Methods: Patients were identified retrospectively through electronic medical records. Inclusion criteria included scleral lens patients treated at the USC Department of Ophthalmology who had reordered a scleral lens at least once in one eye.

The stimulatory G protein Gα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.

Central melanocortin 4 receptors (MC4Rs) stimulate energy expenditure and inhibit food intake. MC4Rs activate the G protein Gα, but whether Gα mediates all MC4R actions has not been established. Individuals with Albright hereditary osteodystrophy (AHO), who have heterozygous Gα-inactivating mutations, only develop obesity when the Gα mutation is present on the maternal allele because of tissue-specific genomic imprinting.