Thoracic electrical impedance tomography for assessing progression of pulmonary dysfunction in ALS.

: We compared thoracic electrical impedance tomography (EIT) with slow vital capacity (SVC) to determine if EIT could monitor pulmonary function in ALS patients longitudinally. : Of 32 ALS patients and 32 age- and sex-matched healthy controls (HCs) initially enrolled in the Pulmonary Function via Impedance Tomography (PuFIT) study, 22 ALS and 20 HCs returned for a follow-up visit ∼3.9 months later.

Real-time fMRI-based neurofeedback to restore brain function in substance use disorders: A systematic review of the literature.

Introduction: Real-time functional magnetic resonance based-neurofeedback (fMRI-neurofeedback) is a neuromodulation tool where individuals self-modulate brain function based on real-time feedback of their brain activity. fMRI-neurofeedback has been used to target brain dysfunction in substance use disorders (SUDs) and to reduce craving, but a systematic synthesis of up-to-date literature is lacking.

Method: Following PRISMA guidelines, we conducted a systematic review of all the literature that examined the effects of fMRI-neurofeedback on individuals with regular psychoactive substance use (PROSPERO pre-registration = CRD42023401137).

Independent effects of transcranial direct current stimulation and social influence on pain.

Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulatory technique with the potential to provide pain relief. However, tDCS effects on pain are variable across existing studies, possibly related to differences in stimulation protocols and expectancy effects. We investigated the independent and joint effects of contralateral motor cortex tDCS (anodal vs cathodal) and socially induced expectations (analgesia vs hyperalgesia) about tDCS on thermal pain.

A Clinically Feasible Electrode Array for 3D Intraoperative Electrical Impedance Tomography-Based Surgical Margin Assessment in Robot-Assisted Radical Prostatectomy.

Objective: A novel small form factor circular electrode array was designed specifically for electrical impedance tomography (EIT) based assessment of surgical margins during robot assisted radical prostatectomy (RARP).

Methods: The electrode array consists of 33 gold-plated electrodes arranged within a 9.5 mm diameter circular footprint on the end of a surgical probe that can be introduced through a standard 12 mm laparoscopic port used during RARP.

Non-invasive biomarkers for detecting progression toward hypovolemic cardiovascular instability in a lower body negative pressure model.

Occult hemorrhages after trauma can be present insidiously, and if not detected early enough can result in patient death. This study evaluated a hemorrhage model on 18 human subjects, comparing the performance of traditional vital signs to multiple off-the-shelf non-invasive biomarkers. A validated lower body negative pressure (LBNP) model was used to induce progression towards hypovolemic cardiovascular instability.

Assessing pulmonary function in ALS using electrical impedance tomography.

Objective: We sought to determine whether thoracic electrical impedance tomography (EIT) could characterize pulmonary function in amyotrophic lateral sclerosis (ALS) patients, including those with facial weakness. Thoracic EIT is a noninvasive, technology in which a multi-electrode belt is placed across the chest, producing real-time impedance imaging of the chest during breathing.

Methods: We enrolled 32 ALS patients and 32 age- and sex-matched healthy controls (HCs) without underlying lung disease.

Rapid patient-specific FEM meshes from 3D smart-phone based scans.

The objective of this study was to describe and evaluate a smart-phone based method to rapidly generate subject-specific finite element method (FEM) meshes. More accurate FEM meshes should lead to more accurate thoracic electrical impedance tomography (EIT) images.The method was evaluated on an iPhonethat utilized an app called Heges, to obtain 3D scans (colored, surface triangulations), a custom belt, and custom open-source software developed to produce the subject-specific meshes.

Towards intraoperative surgical margin assessment: Validation of an electrical impedance-based probe with ex vivo bovine tissue.

Radical prostatectomy (RP) is a common surgical therapy to treat prostate cancer. The procedure has a high positive surgical margin (PSM) rate ranging from 4-48%. Patients with PSMs have a higher rate of cancer recurrence and often undergo noxious adjuvant therapy.

EEG electrode localization with 3D iPhone scanning using point-cloud electrode selection (PC-ES).

Electroencephalography source imaging (ESI) is a valuable tool in clinical evaluation for epilepsy patients but is underutilized in part due to sensitivity to anatomical modeling errors. Accurate localization of scalp electrodes is instrumental to ESI, but existing localization devices are expensive and not portable. As a result, electrode localization challenges further impede access to ESI, particularly in inpatient and intensive care settings.

Development of an Electrical Impedance Tomography Coupled Surgical Stapler for Tissue Characterization.

Objective: This study explores the feasibility of coupling Electrical Impedance Tomography (EIT) to a standard-of-care laparoscopic surgical stapler, stapler+EIT, with the long-term goal of enabling intraoperative tissue differentiation for tumor margin detection.

Methods: Two custom printed-circuit-board-based electrode arrays with 60 and 8 electrodes, respectively, matching the stapler geometry, served as the jaws of an electrode-integrated surrogate stapler+EIT device. The device was evaluated through a series of simulations and bench-top imaging experiments of agar-gel phantoms and bovine tissue samples to evaluate the technique and determine optimal imaging parameters.

Nation-based peer assessment of Europe's Sustainable Development Goal performance.

Less than seven years remain for Europe to meet the targets of the United Nations Sustainable Development Goals (SDGs). However robust and accurate methods for assessing SDG progress are currently lacking. Through the development of several SDG indices, this study addresses this critical knowledge gap by providing the means to accurately identify national 'problem areas' and thereby accelerate SDG achievement.

Bioimpedance Sensing Surgical Drill - In Vivo Porcine Model.

Surgical drilling to place dental implants in the mandible and maxilla is associated high risk of iatrogenic injuries to inferior alveolar nerve and maxillary sinus. Real-time tissue margin sensing at the drill-tip using electrical impedance spectroscopy (EIS) could reduce this risk by providing feedback to surgeons. Studies with saline analogues, ex-vivo tissues, in-situ tissues and computer models have been previously conducted to evaluate these impedance sensors.

Detection of subclinical hemorrhage using electrical impedance: a porcine study.

Analyze the performance of electrical impedance tomography (EIT) in an innovative porcine model of subclinical hemorrhage and investigate associations between EIT and hemodynamic trends.. Twenty-five swine were bled at slow rates to create an extended period of subclinical hemorrhage during which the animal's heart rate (HR) and blood pressure (BP) remained stable from before hemodynamic deterioration, where stable was defined as <15% decrease in BP and <20% increase in HRi.

Novel Electrode Placement in Electrical Bioimpedance-Based Stroke Detection: Effects on Current Penetration and Injury Characterization in a Finite Element Model.

Objective: Reducing time-to-treatment and providing acute management in stroke are essential for patient recovery. Electrical bioimpedance (EBI) is an inexpensive and non-invasive tissue measurement approach that has the potential to provide novel continuous intracranial monitoring-something not possible in current standard-of-care. While extensive previous work has evaluated the feasibility of EBI in diagnosing stroke, high-impedance anatomical features in the head have limited clinical translation.

Iron-Catalyzed Contrasteric Functionalization of Allenic C(sp)-H Bonds: Synthesis of α-Aminoalkyl 1,1-Disubstituted Allenes.

An iron-catalyzed C-H functionalization of simple monosubstituted allenes is reported. An efficient protocol for this process was made possible by the use of a newly developed electron-rich and sterically hindered cationic cyclopentadienyliron dicarbonyl complex as the catalyst and -sulfonyl hemiaminal ether reagents as precursors to iminium ion electrophiles. Under optimized conditions, the use of a mild, functional-group-tolerant base enabled the conversion of a range of monoalkyl allenes to their allenylic sulfonamido 1,1-disubstituted derivatives, a previously unreported and contrasteric regiochemical outcome for the C-H functionalization of electronically unbiased and directing-group-free allenes.

Cardiac eigen imaging: a novel method to isolate cardiac activity in thoracic electrical impedance tomography.

Objective: As the global burden of cardiovascular disease increases, proactive cardiovascular healthcare by means of accurate, precise, continuous, and non-invasive monitoring is becoming crucial. However, no current device is able to provide cardiac hemodynamic monitoring with the aforementioned criterion. Electrical impedance tomography (EIT) is an inexpensive, non-invasive imaging modality that can provide real-time images of internal conductivity distributions that describe physiological activity.

Bioimpedance Sensing Surgical Drill - Computational Modelling and Experimental Validation.

Surgical drilling to fixate dental implants is associated with high risk of injury to the inferior alveolar nerve (IAN) and the maxillary sinus. Current common practice is to use pre-operative radiographs to plan and drill with no real-time feedback of drill tip position with respect to these critical structures. Real-time proximity sensing of the IAN and maxillary sinus by measuring the electrical impedance properties of tissues, directly from the drill tip, while drilling may reduce and eventually eliminate this risk.

A 1 MHz Miniaturized Electrical Impedance Tomography System for Prostate Imaging.

An ASIC for a high frequency electrical impedance tomography (EIT) imaging system for prostate cancer screening is presented. The ASIC enables a small form-factor architecture, which ensures high signal-to-noise ratio (SNR) at MHz frequencies. The 4-channel ASIC was designed and fabricated in a standard CMOS 0.

Phantom Studies of Fused-Data TREIT Using Only Biopsy-Probe Electrodes.

Transrectal electrical impedance tomography (TREIT) is a novel imaging modality being developed for prostate biopsy guidance and cancer characterization. We describe a novel fused-data TREIT (fd-TREIT) system and approach developed to improve imaging robustness and evaluate it on challenging clinically-representative phantoms. The new approach incorporates 8 electrodes (in 2 rows) on a biopsy probe (BP) and 12 electrodes on the face of a transrectal ultrasound (TRUS) probe and includes a biopsy gun, instrument tracking, 3D-printed needle guide, and EIT hardware and software.

A robust and novel electrical impedance metric of pulmonary function in ALS patients.

Objective: Pulmonary function tests (PFTs) are important for assessing respiratory function in amyotrophic lateral sclerosis (ALS) patients. However, weakness of oral and glottal closure, due to concomitant bulbar dysfunction, may result in unreliable PFT values stemming from leakage of air around the breathing tube and through the glottis. In this study, we assessed whether standard thoracic electrical impedance tomography (EIT) could serve as a surrogate measure for PFTs.

Noise-robust bioimpedance approach for cardiac output measurement.

Objective: Congestive heart failure is a problem affecting millions of Americans. A continuous, non-invasive, telemonitoring device that can accurately monitor cardiac metrics could greatly help this population, reducing unnecessary hospitalizations and cost.

Approach: Machine learning (ML) algorithms trained on electrical-impedance tomography (EIT) data are presented for portable cardiac monitoring.

Toward Electrical Impedance Tomography Coupled Ultrasound Imaging for Assessing Muscle Health.

This paper establishes for the first time that a coupled ultrasound (US) and electrical impedance tomography (EIT) system can serve as a non-invasive, spatially localized approach to extract clinically relevant muscle properties. The US/EIT system represents a potential enhancement to electrical impedance myography (EIM), which has shown promise as a non-invasive technology that may have important clinical use in indicating neuromuscular disease status and as a diagnostic tool. A 2.

An Analog Front End ASIC for Cardiac Electrical Impedance Tomography.

In this paper, an end-to-end CMOS application specific integrated circuit (ASIC) for readout channel in a cardiac electrical impedance tomography system is presented. The ASIC consists of an integrated current driver for current injection, an instrumentation amplifier, variable gain amplifier at the analog front end for voltage readout from electrodes, and an on-chip 10-bit successive approximation register analog to digital converter with serial peripheral interface. The ASIC is fabricated in the CMOS 0.

Fused-data transrectal EIT for prostate cancer imaging.

Objective: Prostate cancer is a significant problem affecting 1 in 7 men. Unfortunately, the diagnostic gold-standard of ultrasound-guided biopsy misses 10%-30% of all cancers. The objective of this study was to develop an electrical impedance tomography (EIT) approach that has the potential to image the entire prostate using multiple impedance measurements recorded between electrodes integrated onto an end-fired transrectal ultrasound (TRUS) device and a biopsy probe (BP).

Phantom experiments using soft-prior regularization EIT for breast cancer imaging.

Objective: A soft-prior regularization (SR) electrical impedance tomography (EIT) technique for breast cancer imaging is described, which shows an ability to accurately reconstruct tumor/inclusion conductivity values within a dense breast model investigated using a cylindrical and a breast-shaped tank.

Approach: The SR-EIT method relies on knowing the spatial location of a suspicious lesion initially detected from a second imaging modality. Standard approaches (using Laplace smoothing and total variation regularization) without prior structural information are unable to accurately reconstruct or detect the tumors.