Publications by authors named "Ethan Le"
Article Synopsis
- ACPA are antibodies specifically associated with rheumatoid arthritis (RA), linked to proteins modified by PAD4 enzymes, but the mechanism behind PAD4's role in RA remains unclear.
- Recent findings show that RA patients' neutrophils have unique poly-perforin pores, which are not found in healthy individuals, and these neutrophils contained citrullinated proteins near these pores.
- The study indicates that neutrophil destruction mediated by perforin leads to increased citrullination in RA, especially noted in Felty's syndrome, distinguishing it from other forms of cell death that show less citrullination.
