Publications by authors named "Ethan K MacIsaac"
J Inorg Biochem
January 2025
Article Synopsis
- Human serum albumin (HSA) binds heme b to form a complex ([HSA-Feheme]) which mimics the behavior of globins when modified with chemical derivatives.
- The study aims to create globin-like systems by integrating N-donor ligands (imidazole and 1-methylimidazole) into the [HSA-Feheme] complex and investigating their properties through various spectroscopic methods.
- Results show that the [HSA-Fe(heme)-(1-MeIm)] complex exhibits significantly enhanced nitrite reductase activity, outperforming both the Im derivative and myoglobin, due to an optimized heme binding pocket and specific residue interactions.
