Publications by authors named "Ethan H Crofut"
Article Synopsis
- Doublet microtubules (DMTs) are essential for the protist's ability to swim and cause trichomoniasis, which is the most common non-viral sexually transmitted infection.
- Researchers used cryo-electron microscopy to reveal the structure of DMTs and identified 29 unique proteins, some of which are specific to the parasite and crucial for stabilizing DMTs and locomotion.
- The study also discovered a small molecule, IP6, that may have drug-like properties and could aid in the development of new therapeutics against this infection.
Doublet microtubules (DMTs) are flagellar components required for the protist ( ) to swim through the human genitourinary tract to cause trichomoniasis, the most common non-viral sexually transmitted disease. Lack of DMT structures has prevented structure-guided drug design to manage infection. Here, we determined the cryo-EM structure of native DMTs, identifying 29 unique proteins, including 18 microtubule inner proteins and 9 microtubule outer proteins.
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