Publications by authors named "Ethan Black"
Article Synopsis
- Endothelial cells (ECs) are crucial for heart valve formation, but researchers have struggled to identify specific markers to study their functions in valve development effectively.
- A study identified the gene Cyp26b1, found in the endocardium of developing heart valves, as essential for normal valve development, with its absence leading to thickened aortic valve leaflets and ventricular septal defects in mouse models.
- The research indicates that Cyp26b1 plays a role in regulating retinoic acid-dependent pathways during heart valve morphogenesis, highlighting the need to better understand the expression of cardiac EC genes to address normal and defective valve development.
