Publications by authors named "Eszter Puhl"
Br J Pharmacol
January 2025
Article Synopsis
- Three types of small RNA therapeutics—siRNAs, miRNAs, and ASOs—have advantages over traditional drugs by targeting gene products, offering new treatment avenues for various diseases.
- While these small RNAs are valuable in preclinical research for gene silencing and drug target validation, off-target effects, particularly miRNA-like ones, can complicate results and lead to adverse effects.
- The review discusses strategies such as sequence design and AI-based predictions to minimize these off-target effects, providing a comprehensive overview of current computational methods and experimental validation techniques to support small RNA therapy development.
