Preparation of pH-sensitive beads for NSAID using three-component gel systems.

The aim of this study is to prepare novel pH-sensitive beads to obtain a gastric mucosa protective formulation and to ensure drug delivery into the intestine. Diclofenac sodium was used as a model drug. Bead formation was achieved by ionotropic gelation method using three-component gel system containing sodium alginate (Na-Alg), hydroxyethylcellulose (HEC) and hydroxypropylmethylcellulose (HPMC).

[Formulation of thermoresponsive transdermal therapeutic systems using cellulose derivatives].

The purpose of the present study was to formulate a novel thermoresponsive membrane controlled therapeutic system from Metolose for possible transdermal application. Metolose gel shows thermal gelation property which can be characterized by two (T1, T2) temperatures. A sharp decrease of viscosity can be measured at T1, but gelation can be observed at T2.