Publications by authors named "Eszter Palyu"
Background: The epidemiology of esophageal cancer has changed dramatically over the past 4 decades in many Western populations. We aimed to understand the Hungarian epidemiologic trends of esophageal squamous cell cancer (SCC) and adenocarcinoma (AC).
Methods: We performed a cross-sectional study using data from esophageal cancer patients diagnosed between 1992 and 2018 at eight tertiary referral centers in four major cities of Hungary.
Article Synopsis
- Patients with cirrhosis exhibit an imbalance between processes that promote and inhibit blood clotting, with acute decompensation (AD) showing major changes in von Willebrand factor (VWF) that may increase blood clot risk compared to stable cirrhosis (ST).
- In a study involving various cirrhotic patients and controls, researchers measured VWF levels, ADAMTS13 activity, and C-reactive protein (CRP) levels, finding significant differences between those with AD and ST cirrhosis.
- The presence of ultra-large VWF multimers (ULMWM) in AD patients corresponds with low ADAMTS13 activity and high CRP levels, suggesting these factors play a role in the progression
Aim: To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis (PSC) patients.
Methods: Sera of 67 PSC patients [median age (range): 32 (5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin (AAA IgA/IgG) and gliadin (AGA IgA/IgG)] and for serum level of intestinal fatty acid-binding protein (I-FABP) by ELISA. Markers of lipopolysaccharide (LPS) exposure [LPS binding protein (LBP)] and various anti-microbial antibodies [anti-OMP Plus IgA and endotoxin core IgA antibody (EndoCAb)] were also determined.
Background: Early identification of patients with Crohn's disease (CD) at risk of subsequent complications is essential for adapting the treatment strategy. We aimed to develop a prediction model including clinical and serological markers for assessing the probability of developing advanced disease in a prospective referral CD cohort.
Methods: Two hundred and seventy-one consecutive CD patients (42.
Article Synopsis
- * Methods: Researchers analyzed data from 458 IBD patients (271 with Crohn's disease and 187 with ulcerative colitis) over an average follow-up period of around 57-62 months, testing their blood samples for various APLAs and assessing clinical outcomes based on detailed medical records.
- * Results: The study found that Crohn's disease patients had a significantly higher prevalence of specific APLAs compared to ulcerative colitis patients and healthy controls, while no substantial association was observed between A
The α-chain alleles 1 and 2 of haptoglobin (Hp) molecule account for three phenotypes, which have biologically important differences in their antioxidant, scavenging, and immunomodulatory properties and may thereby influence the course of inflammatory diseases. A follow-up observational study was conducted to assess the association between haptoglobin phenotype and the development of clinically significant bacterial infections in patients with liver cirrhosis. Sera of 336 patients with liver cirrhosis of various etiologies and 384 healthy subjects were investigated.
View Article and Find Full Text PDFBackground: In inflammatory bowel disease (IBD), enhanced inflammatory activity in the gut is thought to increase the risk of bacterial translocation and endotoxemia. In the present study we investigated the association between serum level of lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), and clinical disease activity, high-sensitivity C-reactive protein (hs-CRP), antimicrobial serology profile, NOD2/CARD15 status, and clinical phenotype in a large cohort of Hungarian Crohn's disease (CD) patients.
Methods: In all, 214 well-characterized, unrelated, consecutive CD patients (male/female ratio: 95/119; age: 35.
Aim: To determine the prevalence of a new set of anti-glycan and anti-outer membrane protein (anti-OMP) antibodies in a Hungarian cohort of adult Celiac disease (CD) patients.
Methods: 190 consecutive CD patients [M/F: 71/119, age:39.9 (SD:14.