From genetic risk awareness to overt type 1 diabetes: parental stress in a placebo-controlled prevention trial.

Objective: To evaluate the psychological burden of parents facing increasing risk of type 1 diabetes in their children.

Research Design And Methods: In the population-based Type 1 Diabetes Prediction and Prevention (DIPP) Study, newborn infants with HLA-DQB1-conferred diabetes risk were enrolled in sequential analyses of diabetes-associated autoantibodies. Those persistently positive for at least two autoantibodies were recruited to a randomized double-blinded intervention trial.