Invasive bacterial infection in children with fever and petechial rash in the emergency department: a national prospective observational study.

Objective: To determine the incidence and clinical predictors of invasive bacterial infection (IBI) in well-appearing children who present to the emergency department (ED) with fever and petechiae.

Design: A prospective, observational, multicentre study was conducted in 18 hospitals between November 2017 and October 2019.

Patients: A total of 688 patients were recruited.

Host and environmental factors influencing respiratory secretion of pro-wheezing biomarkers in preterm children.

Cytokines are actively secreted by the respiratory mucosa of preterm children and participate in the pathogenesis of wheezing. This study aimed to identify the factors that could potentially influence respiratory secretion of cytokines in these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm children 1 yr after birth.