Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia.

Background: Ventilator-associated pneumonia (VAP) is one of the most commonly encountered intensive care unit (ICU) acquired infections worldwide. The objective of the study was to identify the immune alteration occurring in patients suffering from VAP at the transcriptomic level and explore its potential use for clinical diagnoses of this disease.

Methods: We performed a prospective observational study in five medical ICUs.