Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database.

Background: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users.

Methods: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database.

[Factors determining antibiotic prescription in primary care].

Introduction: To determine patient and physician-related factors associated with variability in antibiotic prescription.

Material And Methods: Observational study of the prevalence of antibacterial medication prescription >14 years old.

Data Source: official prescriptions, clinical histories and individual health cards.

[High exposure to antibiotics in the population and differences by sex and age].

Purpose: To determine antibiotic use and its distribution by age and gender, as well as the most prescribed therapeutic group.

Design: Observational descriptive with retrospective data.

Settings And Participants: Population from the Lleida (Spain) Health Region receiving antibiotic prescriptions from 2002 to 2007.

Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition.

Soyabean oil-based emulsions high in linoleic acid used in parenteral nutrition (PN) could interfere with immune function and may increase the risk of septic complications. Olive oil-based emulsions, high in oleic acid, could have fewer immune effects. We compared the effects of a soyabean oil-based emulsion v.

Impact of rifampicin addition to clarithromycin in Legionella pneumophila pneumonia.

We evaluated the effectiveness and safety of rifampicin addition to clarithromycin in the treatment of Legionnaires' disease. An observational cohort study was conducted on patients assigned to a Legionnaires' disease outbreak. Of 32 patients with confirmed Legionella pneumonia, 11 received clarithromycin monotherapy and 21 received combination therapy of clarithromycin with rifampicin.

[Paraoxonase 1 gene 192 polymorphism, physical activity and lipoprotein in women].

Background And Objective: Regular physical activity is associated with an increase in high-density lipoprotein cholesterol (HDL-C), whose antioxidant and protective effect for coronary artery disease is well known. Paraoxonase-1 (PON1) is an enzyme related with the antioxidant activity of HDL. The PON1 gene has several genetic polymorphisms; one of them locates in codon 192, whose alleles Q and R are associated with low and high PON1-activity, respectively.