Publications by authors named "Esther Picton-Barlow"
Understanding transmission pathways of important opportunistic, drug-resistant pathogens, such as extended-spectrum beta-lactamase (ESBL)-producing , is essential to implementing targeted prevention strategies to interrupt transmission and reduce the number of infections. To link transmission of ESBL-producing (ESBL-EC) between two sources, single-nucleotide resolution of strains, as well as diversity within and between samples, is required. However, the microbiological methods to best track these pathogens are unclear.
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- Infections caused by Enterobacterales are becoming harder to treat due to increasing antimicrobial resistance, particularly following the switch from chloramphenicol to ceftriaxone for suspected sepsis in Malawi in 2004.
- Surprisingly, while extended-spectrum beta-lactamase (ESBL)-producing bacteria emerged, resistance to chloramphenicol decreased in certain E. coli and Klebsiella strains, hinting at a potential comeback for chloramphenicol.
- Research shows that 31% of the tested Malawian E. coli and Klebsiella isolates have mismatched chloramphenicol susceptibility genotypes and phenotypes; significant changes in cat gene stability suggest chloramphenicol could be reintroduced as