Publications by authors named "Esther Need"
Tumor agnostic ultrasmall nanoprobes for fluorescence-guided surgical resection in peritoneal metastasis.
Eur J Nucl Med Mol Imaging
October 2024
Article Synopsis
- Surgical excision of metastases is crucial for treating peritoneal carcinomatosis, and the success of this procedure largely depends on completely removing the tumor; researchers are exploring the use of novel fluorescent probes to enhance surgical outcomes.
- In this study, ultrasmall porous silica nanoparticles (UPSN) were developed and tested in mice with colorectal and pancreatic cancers, demonstrating effective tumor targeting and imaging capabilities during surgery.
- Results showed that the UPSN, particularly with Cy5 dye, provided superior tumor visibility and safety compared to existing imaging agents, indicating their potential as a valuable tool for improving the precision of tumor resections.
Article Synopsis
- Tumor hypoxia in pediatric malignant rhabdoid tumors (MRT) leads to resistance against radiation therapy, worsening treatment outcomes.
- Researchers repurposed an FDA-approved drug, Atovaquone (AVO), to reduce oxygen consumption in tumors, enhancing their sensitivity to low-dose radiation therapy.
- Using multispectral optoacoustic tomography (MSOT), they monitored oxygen levels in tumors, finding that AVO increased oxygen saturation before radiation treatment, which correlated with improved anti-tumor responses, while resistance to AVO diminished its effectiveness.